Polymerization in Living Organisms for Biomedical Applications

Intra-tissue polymerization as a kind of polymerization reaction in biological tissues has the advantages of good biocompatibility, accurate localization, and dynamic response. In this review, the progress and applications of intra-tissue polymerization technologies in biomedicine are summarized. The biomedical applications of polymerization in different tissues are discussed, including living neural tissues to improve neural device performance, preparation of electronic devices in plants and animals, polymerization in tumor tissues for therapeutic and monitoring purposes, and polymerization in skin tissues for wound monitoring and therapy. Various polymerization strategies, including electrochemical polymerization, enzymatic polymerization, photopolymerization, and free radical polymerization, are used and described in the different intra-tissue polymerization methods. Moreover, the challenges in this field are discussed, such as the precise control of polymerization reactions and the development of biocompatible materials, and the future development direction of this field is also prospected.