外消旋肽组装促进生物催化。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-02-13 DOI:10.1039/d4ob01987c

Mari C. Mañas-Torres , Paola Alletto , Simone Adorinni , Attilio V. Vargiu , Luis Álvarez de Cienfuegos , Silvia Marchesan

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引用次数: 0

摘要

杂手性三肽的外消旋组装提高了酯水解的生物催化活性。氨基酸序列是生物启发的，其特征是组氨酸（His）作为催化活性残基，二苯丙氨酸（Phe-Phe）基序驱动自组装成凝胶的各向异性纳米结构。因此，该研究为设计具有更高活性的绿色生物催化剂提供了关键的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Racemic peptide assembly boosts biocatalysis†

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Racemic peptide assembly boosts biocatalysis†

Racemic assembly of minimalistic heterochiral tripeptides boosts their biocatalytic activity for ester hydrolysis. The amino acidic sequences are bioinspired and feature histidine (His) as a catalytically active residue, and the diphenylalanine (Phe-Phe) motif to drive self-assembly into anisotropic nanostructures that gel. This study thus provides key insights for the design of green biocatalysts with improved activity.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.