{"title":"酿酒酵母发酵的高分子量透明质酸增强皮肤成纤维细胞的抗氧化能力","authors":"Meng Zhang, Doudou Shi, Mimi Cui, Jinyong Li, Wenjing Cheng, Chunhong Pu, Jiachan Zhang, Changtao Wang","doi":"10.1007/s00203-025-04274-7","DOIUrl":null,"url":null,"abstract":"<div><p>In this study, fermented hyaluronic acid (FHA) was obtained by fermentation of hyaluronic acid (HA) with molecular weight ranging from 1200 to 1300 kDa with two strains of<i> Saccharomyces cerevicae</i> (CICC 1308 and CICC 1747). Active substance content and spectral analysis revealed a substantial decrease in FHA molecular weight, accompanied by changes in monosaccharide composition, yet the chemical structure of FHA remained unchanged. Secondly, FHA exhibited a strong ability to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radicals. In hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced human skin fibroblasts (HSF), FHA enhanced superoxide dismutase (SOD) and catalase (CAT) activities and reduced malondialdehyde (MDA) levels, reversing oxidative stress via the <i>Nrf2/Keap1/HO-1</i> signaling pathway. These findings highlight FHA's potential as a natural cosmetic ingredient. Future research should investigate its long-term effects and potential applications in skin care treatments.</p></div>","PeriodicalId":8279,"journal":{"name":"Archives of Microbiology","volume":"207 3","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Saccharomyces cerevisiae fermentation of high molecular weight hyaluronic acid enhanced the antioxidant capacity in skin fibroblasts\",\"authors\":\"Meng Zhang, Doudou Shi, Mimi Cui, Jinyong Li, Wenjing Cheng, Chunhong Pu, Jiachan Zhang, Changtao Wang\",\"doi\":\"10.1007/s00203-025-04274-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this study, fermented hyaluronic acid (FHA) was obtained by fermentation of hyaluronic acid (HA) with molecular weight ranging from 1200 to 1300 kDa with two strains of<i> Saccharomyces cerevicae</i> (CICC 1308 and CICC 1747). Active substance content and spectral analysis revealed a substantial decrease in FHA molecular weight, accompanied by changes in monosaccharide composition, yet the chemical structure of FHA remained unchanged. Secondly, FHA exhibited a strong ability to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radicals. In hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced human skin fibroblasts (HSF), FHA enhanced superoxide dismutase (SOD) and catalase (CAT) activities and reduced malondialdehyde (MDA) levels, reversing oxidative stress via the <i>Nrf2/Keap1/HO-1</i> signaling pathway. These findings highlight FHA's potential as a natural cosmetic ingredient. Future research should investigate its long-term effects and potential applications in skin care treatments.</p></div>\",\"PeriodicalId\":8279,\"journal\":{\"name\":\"Archives of Microbiology\",\"volume\":\"207 3\",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-02-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Microbiology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00203-025-04274-7\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Microbiology","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1007/s00203-025-04274-7","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Saccharomyces cerevisiae fermentation of high molecular weight hyaluronic acid enhanced the antioxidant capacity in skin fibroblasts
In this study, fermented hyaluronic acid (FHA) was obtained by fermentation of hyaluronic acid (HA) with molecular weight ranging from 1200 to 1300 kDa with two strains of Saccharomyces cerevicae (CICC 1308 and CICC 1747). Active substance content and spectral analysis revealed a substantial decrease in FHA molecular weight, accompanied by changes in monosaccharide composition, yet the chemical structure of FHA remained unchanged. Secondly, FHA exhibited a strong ability to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radicals. In hydrogen peroxide (H2O2)-induced human skin fibroblasts (HSF), FHA enhanced superoxide dismutase (SOD) and catalase (CAT) activities and reduced malondialdehyde (MDA) levels, reversing oxidative stress via the Nrf2/Keap1/HO-1 signaling pathway. These findings highlight FHA's potential as a natural cosmetic ingredient. Future research should investigate its long-term effects and potential applications in skin care treatments.
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Research papers must make a significant and original contribution to
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