使用基于临床CT成像的标本特异性增材制造固定装置提高评估小动物骨骼骨整合的准确性

IF 3.3 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-02-11 DOI:10.1016/j.jmbbm.2025.106941

Maximilian Pestel , Jürgen Alphonsus , Stefan Toegel , Andreas Strassl , Johannes Herold , Reinhard Windhager , Emir Benca

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引用次数: 0

摘要

目的在小动物研究中，种植体去除是量化骨整合水平的常用方法。由于种植体尺寸小，在去除实验中精确对准对于获得准确和可重复的结果至关重要。本研究提出了一种利用光子计数检测器计算机断层扫描（PCD-CT）数据和增材制造来改善植入物对准的新方法。方法设计简化有限元模型，探讨种植体错位对拔除试验的影响。此外，利用PCD-CT扫描评估了43只大鼠胫骨的几何形状，随后使用计算机辅助设计和桌面3D打印机设计和制造了特定于标本的定位夹具。通过视觉（目前的技术水平）和投影x线摄影在颅尾（CC）和前后（AP）投影中评估固定装置内标本对准的准确性和精度，以量化真正的错位。结果有限元分析表明，应力和位移对不对准很敏感，可能导致种植体移除测量的大量不准确。视觉评估的统计分析显示，操作者之间和操作者内部的可变性较差至中等（0.336≤ICC≤0.625），与真正的不一致的相关性较低（0.024≤R2≤0.204）。与目视评估（CC: 0.88±0.92°，AP: 1.11±1.15°）相比，夹具内标本对准（CC: 0.23±0.46°，AP: 1.00±0.82°）的准确性和精密度有所提高。结论所提出的标本固定和对准方法依赖于临床影像数据和廉价的3D打印机，为视觉评估提供了一种成本和时间有效的替代方法，可以显着提高骨整合评估的准确性和精密度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Improving accuracy in assessing osseointegration in small animal bone using specimen-specific additively-manufactured fixtures based on clinical CT imaging

查看原文本刊更多论文

Improving accuracy in assessing osseointegration in small animal bone using specimen-specific additively-manufactured fixtures based on clinical CT imaging

Objective

Implant removal is a common method to quantify the level of osseointegration in small animal studies. Due to small implant sizes, precise alignment in removal experiments is crucial to obtain accurate and reproducible results. This study proposes a novel approach using photon counting detector computed tomography (PCD-CT) data and additive manufacturing to improve implant alignment.

Methods

A simplified finite element model was designed to investigate the effect of implant misalignment in removal tests. Additionally, the geometry of 43 rat tibiae was assessed utilizing PCD-CT scans, and subsequently specimen-specific positioning fixtures were designed and manufactured using computer-aided design and tabletop 3D printers. The accuracy and precision of the specimen alignment within the fixtures were assessed both visually (current state of the art) and through projectional radiography in both cranial-caudal (CC) and anterior-posterior (AP) projections to quantify true misalignment.

Results

Finite element analysis demonstrated that stresses and displacements are sensitive to misalignment, potentially leading to substantial inaccuracies in the implant removal measurements. Statistical analysis of visual assessments revealed poor to moderate inter- and intra-operator variability (0.336 ≤ ICC ≤ 0.625) and low correlation with true misalignment (0.024 ≤ R² ≤ 0.204). Specimen alignment within the fixtures (CC: 0.23 ± 0.46°, AP: 1.00 ± 0.82°) showed improvement in accuracy and precision compared to visual assessments (CC: 0.88 ± 0.92°, AP: 1.11 ± 1.15°).

Conclusion

The proposed specimen fixation and alignment, which relies on clinical imaging data and inexpensive 3D printers, offers a cost- and time-effective alternative to visual assessments, which could considerably improve the accuracy and precision in osseointegration assessment.

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.