中国社区老年人尿必需金属及其混合物与代谢综合征及其组分的关系

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2025-02-18 DOI:10.1016/j.jtemb.2025.127623

Panpan Wang , Xuqiu Cheng , Chen Zhang , Jingyuan Lei , Hongli Wang , Yuan Wang , Liang Sun , Bing Hu , Guangbo Qu , Dongmei Zhang , Guimei Chen , Chunmei Liang , Fangbiao Tao , Qingsi Wu , Yuyou Yao , Linsheng Yang

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引用次数: 0

摘要

背景多种必需金属（EMs）对代谢综合征（MetS）的联合作用知之甚少。本研究旨在探讨中国社区居住老年人的EMs与MetS及其组成部分的个体和整体相关性。方法采用电感耦合等离子体质谱（ICP-MS）测定2222例老年人尿液中钼（Mo）、钒(V)、硒（Se）、钙（Ca）、钴（Co）、镁（Mg）等6种微量元素。Logistic回归和限制三次样条（RCS）模型用于评估单次电磁效应。使用基于分位数的g计算（Qgcomp）和贝叶斯核机回归（BKMR）模型来估计多个EMs的总体效果。结果在控制潜在混杂因素后，Mo与MetS呈显著负相关（OR = 0.852, 95 % CI: 0.750 ~ 0.967）。RCS显示Mo与MetS呈负线性相关（总体P = 0.039，非线性P = 0.942）。BKMR和Qgcomp模型均显示EM混合物与MetS呈负相关，其中Mo的权重最高。此外，Mo与高血压呈负相关，V和Se与低高密度脂蛋白胆固醇（HDL-C）呈负相关，而Mg与低HDL-C呈正相关。EM混合物与高血压和低HDL-C呈负相关。结论无论是单独还是混合，Mo与MetS均呈线性负相关。EM混合物与降低MetS风险有关，主要是由Mo驱动的，它降低了高血压的风险。

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Associations of urinary essential metals and their mixture with metabolic syndrome and its components among Chinese community-dwelling older adults

Background

Little is known regarding the joint effect of multiple essential metals (EMs) on metabolic syndrome (MetS). This study aimed to investigate individual and overall correlations of EMs with MetS and its components among Chinese community-dwelling older adults.

Methods

Six urine EMs, including molybdenum (Mo), vanadium (V), selenium (Se), calcium (Ca), cobalt (Co), and magnesium (Mg), were measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in 2222 older adults. Logistic regression and restricted cubic spline (RCS) models were utilized to assess single EM effects. Quantile-based g-computation (Qgcomp) and Bayesian kernel machine regression (BKMR) models were applied to estimate the overall effects of multiple EMs.

Results

After controlling for potential confounders, Mo was significantly inversely connected to MetS (OR = 0.852, 95 % CI: 0.750 ∼ 0.967). RCS displayed a negative linear association of Mo with MetS (P _{for overall} = 0.039, P _{for nonlinearity} = 0.942). Both BKMR and Qgcomp models showed that EM mixture was inversely related to MetS, with Mo having the highest weight. Furthermore, Mo was inversely linked with high blood pressure, and V and Se were inversely linked with low high-density lipoprotein cholesterol (HDL-C), whereas Mg was positively linked with low HDL-C. The EM mixture was negatively correlated with high blood pressure and low HDL-C.

Conclusions

Urine Mo is in a linearly inverse correlation with MetS, individually and as a mixture. The EM mixture is connected to decreased MetS risk, mainly driven by Mo, which decreases the risk of high blood pressure.

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.