维地内酯：天然来源，总合成和药理活性的综合综述

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines Pub Date : 2025-02-01 DOI:10.1016/S1875-5364(25)60821-1

Haiping Cai, Yue Wu, Xiaojin Zhang

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引用次数: 0

摘要

植物衍生的天然产物长期以来一直是开发治疗药物的重要来源。维德内酯（Wedelolactone， WDL）是一种从黄花、金盏花、中国花和三叶藻中分离得到的药物，具有广泛的治疗潜力，包括抗癌、抗炎、抗肥胖、抗肌毒、抗菌、抗糖尿病和组织保护活性。本文综述了WDL的分离、全合成、药理活性、潜在机制和药代动力学性质。此外，它还提供了利用WDL或其衍生物的潜在临床应用和未来药物发现途径的见解，无论是单独使用还是与其他药物联合使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A comprehensive review on wedelolactone: natural sources, total synthesis, and pharmacological activities

Plant-derived natural products have long been a vital source for developing therapeutic drugs. Wedelolactone (WDL), a coumestan isolated from Eclipta prostrata, Wedelia calendulacea, Wedelia chinensis, and Sphagneticola trilobata, demonstrates a broad spectrum of therapeutic potential, including anticancer, anti-inflammatory, anti-obesity, anti-myotoxic, antimicrobial, anti-diabetic, and tissue-protective activities. This review synthesizes information on the isolation, total synthesis, pharmacological activity, underlying mechanisms, and pharmacokinetic properties of WDL. Additionally, it offers insights into potential clinical applications and future drug discovery avenues utilizing WDL or its derivatives, either independently or in combination with other pharmaceuticals.

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来源期刊

Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY

CiteScore

7.50

自引率

4.30%

发文量

2235

期刊介绍： The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.