级联pd催化叠氮化物-异氰化物交叉偶联/环化/内酰胺化反应合成含三环胍多杂环

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-02-11 DOI:10.1021/acs.joc.4c0293010.1021/acs.joc.4c02930

Xiaoming Ma*, Zijie Gao, Jiawei Niu, Sai Zhang, Lingfeng Luo, Shenghu Yan, Qiang Zhang and Wei Zhang*,

引用次数: 0

摘要

研究了一锅法合成三环胍支架的方法。叠氮化物[3 + 2]加合物用于叠氮化物-异氰化物交叉偶联/亲核环化/内酰胺化，得到高度凝聚的多杂环。在连续反应中，广泛的含叠氮多[3 + 2]加合物和异氰酸酯是可耐受的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cascade Pd-Catalyzed Azide-Isocyanide Cross Coupling/Cyclization/Lactamization Reactions for the Synthesis of Tricyclic Guanidine-Containing Polyheterocycles

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Cascade Pd-Catalyzed Azide-Isocyanide Cross Coupling/Cyclization/Lactamization Reactions for the Synthesis of Tricyclic Guanidine-Containing Polyheterocycles

A one-pot synthesis of a tricyclic guanidine scaffold is developed. The azido-bearing [3 + 2] adducts are used for cascade azide-isocyanide cross-coupling/nucleophilic cyclization/lactamization to afford highly condensed polyheterocycles. A wide range of azido-containing [3 + 2] adducts and isocyanides are tolerated in the sequential reactions.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.