电化学驱动的2-炔基芳基肟硫代环化：获得功能化异喹啉

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-02-07 DOI:10.1021/acs.joc.4c0265510.1021/acs.joc.4c02655

Jiajun Hu, Bo Li, Feng Xiong, Yue Xu, Zheyu Li, Linghui Gu*, Wenbo Ma* and Ruhuai Mei*,

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引用次数: 0

摘要

建立了一种无过渡金属的2-炔基芳基肟与二硫族化合物的电化学硫代环化反应，以简洁地组装有价的4-有机氧基异喹啉。该协议通过在用户友好的未分裂细胞设置中不断电解进行。它避开了过渡金属催化剂、化学氧化剂和恶劣反应条件的需要。该方法具有良好的官能团耐受性、显著的区域选择性、易于扩展、反应条件温和以及可转化的4-有机乙醇异喹啉产物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Electrochemically Driven Chalcogenative Cyclization of 2-Alkynyl Aryl Oxime: Access to Functionalized Isoquinolines

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Electrochemically Driven Chalcogenative Cyclization of 2-Alkynyl Aryl Oxime: Access to Functionalized Isoquinolines

A transition-metal-free electrochemical chalcogenative cyclization of 2-alkynyl aryl oxime with dichalcogenides has been established to assemble valuable 4-organochalcogen isoquinolines concisely. This protocol proceeds via constant electrolysis in a user-friendly undivided cell setup. It circumvents the necessity of transition metal catalysts, chemical oxidants, and harsh reaction conditions. The practical utilities of the current protocol were illustrated by excellent functional group tolerance, remarkable regio-selectivity, easy scalability, mild reaction conditions, and transformable 4-organochalcogen isoquinoline products.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.