Sarah Taimur, Michael G Ison, John W Baddley, Maheen Z Abidi
{"title":"实体器官移植受者的虚弱和感染。","authors":"Sarah Taimur, Michael G Ison, John W Baddley, Maheen Z Abidi","doi":"10.1111/tid.14445","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The association between frailty and infection in the transplant population is not well understood. Emerging data suggests that frailty at the time of transplant is associated with increased infection risk in liver and older kidney transplant recipients.</p><p><strong>Methods: </strong>The authors conducted a brief electronic survey of transplant infectious disease (TID) clinicians, to assess clinical practice trends on frailty assessment.</p><p><strong>Results: </strong>Among survey participants, only 40% reported a routine assessment of frailty in transplant candidates and recipients at their institutions, most commonly in liver transplant patients. The majority of respondents (77%) reported not being routinely involved in making clinical decisions utilizing frailty information. Seventy-one percent reported interest in the study of frailty in relation to infections in the transplant host.</p><p><strong>Conclusion: </strong>In this survey of TID clinicians, less than half reported a formal frailty assessment for candidates and recipients at their institutions. TID clinicians are mostly not involved in making clinical decisions related to frailty; however, the majority endorsed interest in frailty and infection research. We need future studies to enhance our understanding of the emerging data on the association between frailty and infection risk in the transplant host.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e14445"},"PeriodicalIF":2.6000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018120/pdf/","citationCount":"0","resultStr":"{\"title\":\"Frailty and Infection in Solid-Organ Transplant Recipients.\",\"authors\":\"Sarah Taimur, Michael G Ison, John W Baddley, Maheen Z Abidi\",\"doi\":\"10.1111/tid.14445\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The association between frailty and infection in the transplant population is not well understood. Emerging data suggests that frailty at the time of transplant is associated with increased infection risk in liver and older kidney transplant recipients.</p><p><strong>Methods: </strong>The authors conducted a brief electronic survey of transplant infectious disease (TID) clinicians, to assess clinical practice trends on frailty assessment.</p><p><strong>Results: </strong>Among survey participants, only 40% reported a routine assessment of frailty in transplant candidates and recipients at their institutions, most commonly in liver transplant patients. The majority of respondents (77%) reported not being routinely involved in making clinical decisions utilizing frailty information. Seventy-one percent reported interest in the study of frailty in relation to infections in the transplant host.</p><p><strong>Conclusion: </strong>In this survey of TID clinicians, less than half reported a formal frailty assessment for candidates and recipients at their institutions. TID clinicians are mostly not involved in making clinical decisions related to frailty; however, the majority endorsed interest in frailty and infection research. We need future studies to enhance our understanding of the emerging data on the association between frailty and infection risk in the transplant host.</p>\",\"PeriodicalId\":23318,\"journal\":{\"name\":\"Transplant Infectious Disease\",\"volume\":\" \",\"pages\":\"e14445\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018120/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Transplant Infectious Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/tid.14445\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transplant Infectious Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/tid.14445","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/19 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Frailty and Infection in Solid-Organ Transplant Recipients.
Background: The association between frailty and infection in the transplant population is not well understood. Emerging data suggests that frailty at the time of transplant is associated with increased infection risk in liver and older kidney transplant recipients.
Methods: The authors conducted a brief electronic survey of transplant infectious disease (TID) clinicians, to assess clinical practice trends on frailty assessment.
Results: Among survey participants, only 40% reported a routine assessment of frailty in transplant candidates and recipients at their institutions, most commonly in liver transplant patients. The majority of respondents (77%) reported not being routinely involved in making clinical decisions utilizing frailty information. Seventy-one percent reported interest in the study of frailty in relation to infections in the transplant host.
Conclusion: In this survey of TID clinicians, less than half reported a formal frailty assessment for candidates and recipients at their institutions. TID clinicians are mostly not involved in making clinical decisions related to frailty; however, the majority endorsed interest in frailty and infection research. We need future studies to enhance our understanding of the emerging data on the association between frailty and infection risk in the transplant host.
期刊介绍：
Transplant Infectious Disease has been established as a forum for presenting the most current information on the prevention and treatment of infection complicating organ and bone marrow transplantation. The point of view of the journal is that infection and allograft rejection (or graft-versus-host disease) are closely intertwined, and that advances in one area will have immediate consequences on the other. The interaction of the transplant recipient with potential microbial invaders, the impact of immunosuppressive strategies on this interaction, and the effects of cytokines, growth factors, and chemokines liberated during the course of infections, rejection, or graft-versus-host disease are central to the interests and mission of this journal.
Transplant Infectious Disease is aimed at disseminating the latest information relevant to the infectious disease complications of transplantation to clinicians and scientists involved in bone marrow, kidney, liver, heart, lung, intestinal, and pancreatic transplantation. The infectious disease consequences and concerns regarding innovative transplant strategies, from novel immunosuppressive agents to xenotransplantation, are very much a concern of this journal. In addition, this journal feels a particular responsibility to inform primary care practitioners in the community, who increasingly are sharing the responsibility for the care of these patients, of the special considerations regarding the prevention and treatment of infection in transplant recipients. As exemplified by the international editorial board, articles are sought throughout the world that address both general issues and those of a more restricted geographic import.
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