甲硝唑引起的急性脑白质病的快速解决的罕见表现：一个病例报告。

IF 2.4 3区医学 Q2 CLINICAL NEUROLOGY

Neuroradiology Pub Date : 2025-03-01 Epub Date: 2025-02-19 DOI:10.1007/s00234-025-03566-5

Govind Singh Mann, Neeti Ajay Gupta, Nitin Jain

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引用次数: 0

摘要

目的：甲硝唑是一种广泛使用的抗微生物药物，通常耐受性良好，但其不良反应很少表现为共济失调、构音障碍和脑病。很少会以甲硝唑诱发脑病的形式引起严重的神经毒性。方法：我们报告了一位48岁的女性，在服用甲硝唑12天后出现急性小脑症状和感觉改变。结果：磁共振成像（MRI）显示异常弥漫性脑白质病，累及小脑、脑干和脑白质，停药后临床和放射学迅速消退。结论：该病例强调了早期识别症状和立即停用甲硝唑的重要性，以防止不可逆的神经系统后遗症，即使在有限暴露的病例中也是如此。

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A rare presentation of acute onset metronidazole-induced leukoencephalopathy with rapid resolution: a case report.

Purpose: Metronidazole is a widely used antimicrobial and is generally well-tolerated, but its adverse effects can rarely manifest as ataxia, dysarthria, and encephalopathy. Rarely it can cause severe neurological toxicity in the form of Metronidazole-Induced Encephalopathy.

Methods: We report a 48-year-old female with acute cerebellar symptoms and altered sensorium following a 12-day course of Metronidazole.

Results: Magnetic Resonance Imaging (MRI) revealed unusual diffuse leukoencephalopathy involving the cerebellar, brainstem, and cerebral white matter with rapid clinical and radiological resolution occurred after discontinuation.

Conclusions: This case highlights the importance of early recognition of symptoms and immediate discontinuation of Metronidazole to prevent irreversible neurological sequelae, even in cases with limited exposure.

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来源期刊

Neuroradiology 医学-核医学

CiteScore

5.30

自引率

3.60%

发文量

214

审稿时长

4-8 weeks

期刊介绍： Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.