N(6)-甲基腺苷（m6a）修饰在癌症中的作用：最新进展和未来方向。

IF 4.9 3区生物学 Q1 BIOLOGY

EXCLI Journal Pub Date : 2025-01-15 eCollection Date: 2025-01-01 DOI:10.17179/excli2024-7935

Xiaozhou Xie, Zhen Fang, Haoyu Zhang, Zheng Wang, Jie Li, Yuchen Jia, Liang Shang, Feng Cao, Fei Li

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引用次数: 0

摘要

N(6)-甲基腺苷（m6A）修饰是真核rna中最丰富、最普遍的内部修饰。m6A修饰在癌症中的作用是近年来研究的热点，并得到了广泛的探讨。m6A修饰已被证明通过调节不同的靶分子来调节癌症的发生和进展。本文综述了近年来m6A修饰在癌症中的研究进展，并对未来的研究方向，特别是分子靶向药物的发展进行了展望。另见图解摘要（图1）。1）.

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The role of N(6)-methyladenosine (m6a) modification in cancer: recent advances and future directions.

N(6)-methyladenosine (m6A) modification is the most abundant and prevalent internal modification in eukaryotic mRNAs. The role of m6A modification in cancer has become a hot research topic in recent years and has been widely explored. m6A modifications have been shown to regulate cancer occurrence and progression by modulating different target molecules. This paper reviews the recent research progress of m6A modifications in cancer and provides an outlook on future research directions, especially the development of molecularly targeted drugs. See also the graphical abstract(Fig. 1).

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来源期刊

EXCLI Journal BIOLOGY-

CiteScore

8.00

自引率

2.20%

发文量

审稿时长

6-12 weeks

期刊介绍： EXCLI Journal publishes original research reports, authoritative reviews and case reports of experimental and clinical sciences. The journal is particularly keen to keep a broad view of science and technology, and therefore welcomes papers which bridge disciplines and may not suit the narrow specialism of other journals. Although the general emphasis is on biological sciences, studies from the following fields are explicitly encouraged (alphabetical order): aging research, behavioral sciences, biochemistry, cell biology, chemistry including analytical chemistry, clinical and preclinical studies, drug development, environmental health, ergonomics, forensic medicine, genetics, hepatology and gastroenterology, immunology, neurosciences, occupational medicine, oncology and cancer research, pharmacology, proteomics, psychiatric research, psychology, systems biology, toxicology