靶向颗粒酶B的环肽：作为PET显像剂的潜在应用。

IF 4 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2025-01-06 eCollection Date: 2025-02-13 DOI:10.1021/acsmedchemlett.4c00608

Qi-Long Hu, Steven H Liang

引用次数: 0

摘要

本专利申请涉及大环肽及其放射性标记衍生物，通常如式1所示。这些化合物与颗粒酶B （GzmB）选择性结合，并具有与GzmB水平升高相关的疾病或疾病的成像潜力。这些情况包括癌症免疫治疗、自身免疫、伤口愈合和炎症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cyclic Peptides Targeting Granzyme B: Potential Applications as PET Imaging Agents.

This patent application pertains to macrocyclic peptides and their radiolabeled derivatives, generally represented by Formula I. These compounds exhibit selective binding to Granzyme B (GzmB) and hold the potential for imaging disease or disorders associated with elevated GzmB levels. Such conditions include cancer immunotherapy, autoimmunity, wound healing, and inflammation.

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.