日本成人恶性肠套叠的特点

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY

JGH Open Pub Date : 2025-02-20 DOI:10.1002/jgh3.70118

Shogo Kitahata, Ayaka Nakamura, Yuka Kimura, Mai Fukumoto, Kana Matsuoka, Takuya Matsuda, Kazuya Murakawa, Taisei Murakami, Kei Onishi, Hirofumi Izumoto, Kozue Kanemitsu-Okada, Tomoe Kawamura, Taira Kuroda, Junko Matsuoka, Fujimasa Tada, Hideki Miyata, Atsushi Hiraoka, Kazuhiro Tange, Yasunori Yamamoto, Eiji Takeshita, Yoshiou Ikeda, Shinya Furukawa, Eiji Tsubouchi, Tomoyuki Ninomiya, Yoichi Hiasa

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引用次数: 0

摘要

目的成人肠套叠常与器质性疾病相关。然而，很少有研究调查日本患者的AI原因。本研究旨在阐明日本患者恶性肿瘤所致人工智能的临床特点。方法与结果选取2013 - 2021年在我院确诊的日本AI患者54例（≥20岁），按AI病因分为两组(恶性组，n = 26；其他疾病组，n = 28)。回顾性评价患者的临床特征。恶性肿瘤组患者年龄明显大于其他疾病组（p < 0.001）。年龄作为恶性肿瘤所致AI相关因素的截止值为64岁（曲线下面积：0.78,95%可信区间[CI]: 0.65-0.90）。恶性AI慢性症状（≤14天）出现频率显著高于急性（≤4天）和亚急性（4 ~ 14天）出现频率（p = 0.010和p = 0.027）。恶性组中结肠型AI明显多于小肠型和回盲型（p < 0.001）。多因素分析显示，年龄≥64岁、慢性症状和结肠类型与恶性肿瘤所致AI独立相关(校正优势比[OR] 16.00, 95% CI 1.23-208.00；调整后OR 32.70, 95% CI 1.50-712.00；调整OR 31.20, 95% CI分别为2.68-363.00)。结论高龄（≥64岁）、慢性症状和结肠内AI是恶性AI的特征。

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Characteristics of Adult Intussusception due to Malignancy in Japanese Patients

Aims

Adult intussusception (AI) is often associated with organic diseases. However, few studies have examined the causes of AI in Japanese patients. This study aimed to elucidate the clinical characteristics of AI due to malignancy in Japanese patients.

Methods and Results

From 2013 to 2021, 54 Japanese patients with AI (≥ 20 years) diagnosed at our hospital were enrolled and divided into two groups according to the cause of AI (malignancy group, n = 26; other diseases group, n = 28). The patients' clinical characteristics were retrospectively evaluated. Patients in the malignancy group were significantly older than those in the other diseases group (p < 0.001). The cutoff value for age as a factor associated with AI due to malignancy was 64 years (area under the curve: 0.78, 95% confidence interval [CI]: 0.65–0.90). The frequency of chronic symptoms (> 14 days) in AI due to malignancy was significantly higher than the frequencies of acute (≤ 4 days) and subacute (4–14 days) symptoms (p = 0.010 and p = 0.027, respectively). The colonic type of AI was significantly more common than the small intestinal and ileocecal types in the malignancy group (both p < 0.001). Multivariate analysis showed that age of ≥ 64 years, chronic symptoms, and the colonic type were independently associated with AI due to malignancy (adjusted odds ratio [OR] 16.00, 95% CI 1.23–208.00; adjusted OR 32.70, 95% CI 1.50–712.00; adjusted OR 31.20, 95% CI 2.68–363.00, respectively).