3,12-二氧基-5 - β-胆碱-24-酸新衍生物的合成及其降糖性能

IF 1.7 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
O. V. Salomatina, S. A. Borisov, M. V. Khvostov, N. I. Komarova, O. A. Luzina, N. F. Salakhutdinov
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引用次数: 0

摘要

以脱氧胆酸的动物代谢物为原料,通过几种合成方法合成了含有不同取代基的3,12-二氧氧-5β-胆碱-24-酸的1,2,4-和1,3,4-恶二唑衍生物库。对四氧嘧啶诱导的小鼠糖尿病模型的降糖活性筛选结果显示,合成的化合物含有24-no -3,12-二氧氧-5β-胆碱和邻吡啶基团,在第8天通过1,3,4-异二唑连接体连接,使血糖水平降低到与正常动物基本相同。这种化合物的延迟效应可能与影响参与碳水化合物和脂质代谢的基因有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis and hypoglycemic properties of new derivatives of 3,12-dioxo-5β-cholan-24-oic acid

A library of 1,2,4- and 1,3,4-oxadiazole derivatives of 3,12-dioxo-5β-cholan-24-oic acid containing various substituents at the oxadiazole rings was synthesized from the available animal metabolite of deoxycholic acid via several synthetic approaches. The acquired results of screening of the hypoglycemic activity on the model of alloxan-induced diabetes mellitus in mice revealed for the synthesized compounds that the product containing the 24-nor-3,12-dioxo-5β-cholan and o-pyridine moieties are linked via the 1,3,4-oxadiazole linker on the 8th day reduce the glucose level almost to that in the intact animals. The delayed effect of this compound is presumably related to the influence on the work of genes involved in carbohydrate and lipid metabolisms.

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来源期刊
Russian Chemical Bulletin
Russian Chemical Bulletin 化学-化学综合
CiteScore
2.70
自引率
47.10%
发文量
257
审稿时长
3-8 weeks
期刊介绍: Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.
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