对巴西某教学医院新冠肺炎后综合征患者的人口学、流行病学和临床特征进行了随访

IF 3 4区医学 Q2 INFECTIOUS DISEASES

Brazilian Journal of Infectious Diseases Pub Date : 2025-02-19 DOI:10.1016/j.bjid.2025.104509

João Paulo Borges de Melo, Alex Eduardo da Silva, Leandro Resende Yamamoto, Taciana Fernandes Araújo Ferreira, Gustavo José Luvizutto, Fernando Freitas Neves, Kelly Cristina Santos, Roger Lopes Batista, Isabel Cunha Santos, Francielle Schiavoni, Mario León Silva-Vergara

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引用次数: 0

摘要

covid后综合征（PCS）发生在严重急性呼吸系统综合征冠状病毒（SARS-CoV-2感染）后数周，发生率为10% - 35%，症状范围广泛，可持续数月或数年，并显著降低患者的生活质量。目的描述门诊诊断为PCS的患者的临床、流行病学和进化方面的情况。研究方法：两性个体；出现提示PCS症状且先前已确诊为SARS-CoV-2感染的18岁青少年也包括在内。每月由多学科小组进行临床评估，必要时进行实验室检查。结果2021年6月~ 2022年6月共确诊PCS 92例，其中女性60例（65.2%），平均年龄49.1岁。在61例（66.3%）病例中，SARS-CoV-2感染发生在2021年1月至11月之间。轻症55例（59.7%），中重度31例（36.0%）。大多数PCS病例发生在患有轻度COVID-19的个体中。主要症状为慢性疲劳59例（68.6%），脑雾68例（73.4%），肌痛和关节痛44例（47.8%），痉挛和感觉异常40例（46.5%）。观察到的主要合并症是高血压、肥胖和糖尿病。在那些表现出严重形式的COVID-19的病例中，症状的持续时间更长。大多数患者在几个月内经历了逐渐和渐进的改善。该队列PCS患者的概况与其他报道相似。大量的症状是显著的，具有可变的表现和演变，其频率超过了以前在大型荟萃分析中描述的。由病毒、自身免疫和直接有机损伤介导的炎症现象与本综合征的发生有关。

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Demographic, epidemiological and clinical profile of patients with post-COVID syndrome followed at a teaching hospital in Brazil

Introduction

Post-COVID Syndrome (PCS), occurs several weeks after Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2 infection), has a frequency of 10 %‒35 % of cases, presents a wide range of symptoms that can persist for months or years and markedly reduces the quality of life of patients.

Objective

To describe clinical, epidemiological and evolutionary aspects of a cohort of patients diagnosed with PCS followed on an outpatient basis.

Methodology

Individuals of both sexes, > 18-years old who presented symptoms suggestive of PCS and had previously confirmed SARS-CoV-2 infection were included. Clinical evaluation was carried out monthly by a multidisciplinary team, and if necessary laboratorial exams were performed.

Results

From June 2021 to June 2022, 92 cases of PCS were diagnosed, of which 60 (65.2 %) were female and the average age was 49.1 years. In 61 (66.3 %) of the cases, SARS-CoV-2 infection occurred between January and November 2021. In 55 (59.7 %) of the cases the symptoms were mild, while 31 (36.0 %) were moderate or severe cases. Most cases of PCS occurred in individuals with the mild form of COVID-19. The predominant symptoms were chronic fatigue in 59 (68.6 %) cases, brain fog in 68 (73.4 %), myalgias and arthralgias in 44 (47.8 %), cramps and paresthesia's in 40 (46.5 %). The main comorbidities observed were high blood pressure, obesity and diabetes mellitus. The persistence of symptoms was greater in those cases who presented severe forms of COVID-19. Most patients experienced gradual and progressive improvement over the months.

Discussion

The profile of patients with PCS in this cohort is similar to other reports. A great number of symptoms is remarkable with variable presentation and evolution and their frequency exceeds that previously described in a large meta-analysis. Inflammatory phenomena mediated by the virus, autoimmunity and direct organic damage have been implicated in the genesis of this syndrome.

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来源期刊

Brazilian Journal of Infectious Diseases 医学-传染病学

CiteScore

5.50

自引率

0.00%

发文量

925

审稿时长

41 days

期刊介绍： The Brazilian Journal of Infectious Diseases is the official publication of the Brazilian Society of Infectious Diseases (SBI). It aims to publish relevant articles in the broadest sense on all aspects of microbiology, infectious diseases and immune response to infectious agents. The BJID is a bimonthly publication and one of the most influential journals in its field in Brazil and Latin America with a high impact factor, since its inception it has garnered a growing share of the publishing market.