PM2.5暴露对胎盘及其相关代谢产物的影响：一项出生队列研究

IF 6.1 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Ecotoxicology and Environmental Safety Pub Date : 2025-02-19 DOI:10.1016/j.ecoenv.2025.117891

Kuancheng Wang , Liyi Zhang , Qiang Li , Siqi Xu , Pengpeng Wang , Huijing Shi , Yunhui Zhang , Jiufeng Li

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引用次数: 0

摘要

胎盘是胎儿生长的重要器官。怀孕期间的空气污染可能通过胎盘功能障碍对后代造成不利影响。然而，PM2.5对胎盘影响的代谢物尚未得到很好的研究。从上海母婴对队列中随机抽取329名孕妇。分别采用个体空气采样法和卫星暴露评估模式评估妊娠期PM2.5暴露水平。分娩时由妇产科医师测量胎盘重量、长度、宽度和厚度。采用超高效液相色谱-串联质谱法（UHPLC-MS/MS）定量测定妊娠前、晚期血清代谢物。采用广义估计方程和多元线性回归分析PM2.5与胎盘特征的关系。利用限制三次样条（RCS）绘制了暴露-响应关系。基于中间相遇的方法，我们探索了PM2.5对胎盘影响的代谢物。发现胎盘宽度（βTrimester2=-0.497, 95 %CI: - 0.801, - 0.193），（βTrimester3=-0.279, 95 %CI: - 0.543, - 0.016）和绒毛膜盘面积（βTrimester2=-12.634,95 %CI: - 21.698, - 3.570），（βTrimester3=-9.113, 95 %CI: - 17.113, - 1.112）与妊娠中晚期暴露于PM2.5之间存在相关性。个体空气采样和基于卫星的方法评估的胎盘特征与PM2.5暴露之间的关联是一致的。l -精氨酸（L-Arg）、辛酸（CA）、牛磺酸脱氧胆酸（TUDCA）、甘氨酸（Gly-Pro）、麦芽糖糖（MT）和n -乙酰神经酸（NANA）在PM2.5暴露对妊娠晚期胎盘绒毛膜盘面积的影响中起中介作用。结论妊娠中期和晚期可能是PM2.5暴露下胎盘异常的敏感窗口期。辛酸（CA）、甘氨酸（Gly-Pro）和n -乙酰神经酸（NANA）在PM2.5暴露对胎盘的影响中起关键作用。本研究提供了胎盘暴露于PM2.5的潜在生物标志物，为未来的研究和检测提供了机会。

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The effect of PM2.5 exposure on placenta and its associated metabolites: A birth cohort study

The placenta is an important organ for fetal growth. Air pollution during pregnancy may cause adverse effects on offsprings via placental dysfunction. However, the metabolites underlie the effects of PM_2.5 on placenta have not been well studied. 329 pregnant women were randomly selected from the Shanghai Maternal-Child Pairs Cohort. Gestational PM_2.5 exposure levels were assessed using individual air sampling method and satellite-based exposure assessment mode, respectively. Placental weight, length, width and thickness were measured by obstetrician-gynecologist at the time of delivery. Ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was used to quantify metabolites in serum from the first and third trimester. Associations between PM_2.5 and placental characteristics were analyzed by generalized estimating equation and multiple linear regression. The exposure-response relationship was plotted using restricted cubic splines (RCS). Based on the meet-in-the-middle approach, the metabolites underlying the effects of PM_2.5 on placenta were explored. The associations between placental width (β_Trimester2=-0.497, 95 %CI: −0.801, −0.193), (β_Trimester3=-0.279, 95 % CI: −0.543, −0.016) and chorionic disk area (β_Trimester2=-12.634,95 %CI: −21.698, −3.570), (β_Trimester3=-9.113, 95 %CI: −17.113, −1.112) with PM_2.5 exposure at the second and third trimester were found. The associations between placental characteristics with PM_2.5 exposure assessed by individual air sampling and satellite-based methods were consistent. L-arginine (L-Arg), caprylic acid (CA), tauroursodeoxycholic acid (TUDCA), glycylproline (Gly-Pro), maltotriose (MT) and N-acetylneuramic acid (NANA) intermediate the effect of PM_2.5 exposure on placental chorionic disk area in the third trimester.

Conclusion

The second and third trimesters may be the sensitive windows of placental abnormalities to PM_2.5 exposure. Caprylic acid (CA), glycylproline (Gly-Pro), and N-acetylneuramic acid (NANA) play a key role on the effects of PM_2.5 exposure on placenta. This study provides potential biomarkers of placental exposure to PM_2.5, providing an opportunity for future research as well as detection.

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来源期刊

Ecotoxicology and Environmental Safety 环境科学-毒理学

CiteScore

12.10

自引率

5.90%

发文量

1234

审稿时长

88 days

期刊介绍： Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.