静脉蛋白中间细丝的非常规作用

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-02-19 DOI:10.1016/j.ceb.2025.102483

Xinyi Huang , Shuangshuang Zhao , Yifan Xing , Xuedi Gao , Chenglin Miao , Yuhan Huang , Yaming Jiu

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引用次数: 0

摘要

Vimentin是一种III型中间丝蛋白（IF），因其在结构生物学和细胞动力学中的交叉作用而得到广泛认可，影响决定细胞命运和功能的各种途径。虽然这些功能已经被广泛表征，但对于vimentin在调节一系列细胞过程中的传统细胞骨架作用之外的更广泛影响的理解仍然有限。本文就vimentin的细胞外功能、膜受体特性以及对基因表达和细胞代谢的调控作用等方面进行了综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The unconventional role of vimentin intermediate filaments

Vimentin, a type III intermediate filament (IF) protein, is well-recognized for its role at the intersection of structural biology and cellular dynamics, influencing various pathways that determine cell fate and function. While these functions have been extensively characterized, there is still limited understanding of vimentin's broader impact beyond its traditional cytoskeletal roles in regulating a spectrum of cellular processes. This review explores the novel and unconventional roles of vimentin, with a focus on its extracellular functions, membrane receptor properties, and regulatory influence on gene expression and cellular metabolism.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.