通过非消耗臭氧的二卤氟乙酸乙酯获取2,2‐卤氟双环[1.1.1]戊烷

IF 4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-02-18 DOI:10.1002/adsc.202401475

Ziyue Zhu, Jiaqi Tang, Matthew Coe, Alexander Knieb, Yijie Xu, Daniel Lin, Chao Zhang, G. K. Surya Prakash

引用次数: 0

摘要

报道了一种操作简单的方案，通过市售的、廉价的、不消耗臭氧的、稳定的试剂来获取2,2‐氯氟和2,2‐溴氟双环戊烷（bcp）。由此产生的BCP产物在多种合成相关的后功能化反应中具有耐受性。还包括制备bcp的克级反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Access to 2,2-Halofluorobicyclo[1.1.1] Pentanes via Non Ozone-Depleting Ethyl Dihalofluoroacetate

查看原文本刊更多论文

Access to 2,2-Halofluorobicyclo[1.1.1] Pentanes via Non Ozone-Depleting Ethyl Dihalofluoroacetate

An operationally simple protocol to access 2,2-chlorofluoro-, and 2,2-bromofluorobicyclopentanes (BCPs) via commercially available, inexpensive, non-ozone depleting, and bench stable reagents is reported. The resulting BCP products are tolerated in diverse, synthetically relevant post-functionalization reactions. Gram-scale reactions to prepare the BCPs are also included.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.