在患有严重疟疾的儿童中，G6PD缺乏与急性肾损伤（独立于溶血性并发症）的风险增加有关。

IF 4.5 2区医学 Q2 IMMUNOLOGY

Journal of Infectious Diseases Pub Date : 2025-07-30 DOI:10.1093/infdis/jiaf080

Ruth Namazzi, Caroline Kazinga, Giselle Lima-Cooper, Claire Liepmann, Michael J Goings, Olivia Bednarski, Marco Abreu, Tae-Hwi Schwantes-An, Anthony Batte, Robert O Opoka, Chandy C John, Andrea L Conroy

{"title":"在患有严重疟疾的儿童中，G6PD缺乏与急性肾损伤（独立于溶血性并发症）的风险增加有关。","authors":"Ruth Namazzi, Caroline Kazinga, Giselle Lima-Cooper, Claire Liepmann, Michael J Goings, Olivia Bednarski, Marco Abreu, Tae-Hwi Schwantes-An, Anthony Batte, Robert O Opoka, Chandy C John, Andrea L Conroy","doi":"10.1093/infdis/jiaf080","DOIUrl":null,"url":null,"abstract":"Acute kidney injury (AKI) is common and predicts mortality in severe malaria. Studies have reported an increased incidence of AKI in males with hemolytic features of severe malaria. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked enzymopathy, can induce hemolysis. We evaluated whether the G6PD African allele (A-) was associated with AKI in children with severe malaria. The prevalence of G6PD deficiency was 16.7% among hemizygous male children and 2.4% in female children. G6PD deficiency was associated with 2.56-fold odds of AKI (95% confidence interval, 1.33-4.93; P = .005), adjusting for age, sex, site, nutritional status, and features of hemolysis.","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"127-132"},"PeriodicalIF":4.5000,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308644/pdf/","citationCount":"0","resultStr":"{\"title\":\"Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated With Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children With Severe Malaria.\",\"authors\":\"Ruth Namazzi, Caroline Kazinga, Giselle Lima-Cooper, Claire Liepmann, Michael J Goings, Olivia Bednarski, Marco Abreu, Tae-Hwi Schwantes-An, Anthony Batte, Robert O Opoka, Chandy C John, Andrea L Conroy\",\"doi\":\"10.1093/infdis/jiaf080\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Acute kidney injury (AKI) is common and predicts mortality in severe malaria. Studies have reported an increased incidence of AKI in males with hemolytic features of severe malaria. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked enzymopathy, can induce hemolysis. We evaluated whether the G6PD African allele (A-) was associated with AKI in children with severe malaria. The prevalence of G6PD deficiency was 16.7% among hemizygous male children and 2.4% in female children. G6PD deficiency was associated with 2.56-fold odds of AKI (95% confidence interval, 1.33-4.93; P = .005), adjusting for age, sex, site, nutritional status, and features of hemolysis.\",\"PeriodicalId\":50179,\"journal\":{\"name\":\"Journal of Infectious Diseases\",\"volume\":\" \",\"pages\":\"127-132\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2025-07-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308644/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Infectious Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/infdis/jiaf080\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/infdis/jiaf080","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

急性肾损伤（AKI）在重症疟疾中很常见，并预示着死亡率。有研究报道，男性有SM溶血特征的AKI发病率增加。G6PD缺乏症是一种x连锁酶病，可引起溶血。我们评估了G6PD非洲等位基因（A-）是否与严重疟疾患儿的AKI相关。G6PD缺乏症在半合子男性中患病率为16.7%，在女性中患病率为2.4%。G6PD缺乏与AKI的2.56倍几率相关（95% CI， 1.33至4.93,p=0.005），调整了年龄、性别、部位、营养状况和溶血特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated With Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children With Severe Malaria.

Acute kidney injury (AKI) is common and predicts mortality in severe malaria. Studies have reported an increased incidence of AKI in males with hemolytic features of severe malaria. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked enzymopathy, can induce hemolysis. We evaluated whether the G6PD African allele (A-) was associated with AKI in children with severe malaria. The prevalence of G6PD deficiency was 16.7% among hemizygous male children and 2.4% in female children. G6PD deficiency was associated with 2.56-fold odds of AKI (95% confidence interval, 1.33-4.93; P = .005), adjusting for age, sex, site, nutritional status, and features of hemolysis.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.