在下颌推进装置治疗打鼾和睡眠呼吸暂停期间,使用卡罗林斯卡嗜睡量表估计白天嗜睡:一项随机对照试验的二次分析。

IF 2 4区 医学 Q3 CLINICAL NEUROLOGY
Marie Marklund, Bo Carlberg, Lars Forsgren, Helene Rietz, Tommy Olsson, Karl A Franklin
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引用次数: 0

摘要

目的:下颌推进装置治疗对日间嗜睡的影响尚不清楚。在这里,我们使用卡罗林斯卡嗜睡量表评估下颌推进装置对白天嗜睡的影响。方法:随机选取88例打鼾患者,与呼吸暂停-低呼吸指数、性别、呼吸暂停-低呼吸指数和全职工作有关。结果:在特定的时间间隔内,下颌前移装置组的Karolinska嗜睡量表得分低于假牙装置组。下颌推进装置治疗的积极效果出现在整个星期的起床时间和午餐前,以及工作日午餐前的中间四分位数。调整后的干预之间的差异倾向于下颌推进装置治疗几乎一个单位,并使卡罗林斯卡睡意量表在醒来和午餐前的得分正常化。此外,晚餐前下颌推进装置治疗在整个星期、工作日和周末的最高四分位数均有积极作用。结论:用于治疗打鼾和睡眠呼吸暂停的下颌推进装置可以减少白天的嗜睡,特别是在醒来和午餐前,但在晚餐前有一些好处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Daytime sleepiness estimated using the Karolinska Sleepiness Scale during mandibular advancement device therapy for snoring and sleep apnea: a secondary analysis of a randomized controlled trial.

Daytime sleepiness estimated using the Karolinska Sleepiness Scale during mandibular advancement device therapy for snoring and sleep apnea: a secondary analysis of a randomized controlled trial.

Purpose: The effect of mandibular advancement device therapy on daytime sleepiness remains unclear. Here, we evaluate the effect of a mandibular advancement device on daytime sleepiness using the Karolinska Sleepiness Scale.

Methods: We randomized 88 snoring patients with an apnea-hypopnea index < 30 and daytime sleepiness to a mandibular advancement device or a sham device for four months. The Karolinska Sleepiness Scale, which measures grades of sleepiness from 1 (very alert) to 9 (very sleepy), was used for seven consecutive days, four times each day. The results were analyzed with quantile regression at quartiles controlling for baseline, age, body mass index (kg/m2), sex, apnea-hypopnea index, and full-time work.

Results: The Karolinska Sleepiness Scale score was lower with the mandibular advancement device than with the sham device at specific time intervals. The positive effect of mandibular advancement device therapy occurred at wake up and before lunch during the whole week and before lunch on weekdays at the middle quartile. The adjusted differences between the interventions favored mandibular advancement device therapy by almost one unit and normalized the Karolinska Sleepiness Scale scores at wake up and before lunch. In addition, there were positive effects of mandibular advancement device therapy before dinner at the highest quartile during the whole week, on weekdays, and on the weekend.

Conclusion: Mandibular advancement devices used for snoring and sleep apnea reduce daytime sleepiness, particularly at wake up and before lunch, but provide some benefit before dinner.

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来源期刊
Sleep and Breathing
Sleep and Breathing 医学-呼吸系统
CiteScore
5.20
自引率
4.00%
发文量
222
审稿时长
3-8 weeks
期刊介绍: The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep. Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.
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