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IF 2.4 4区医学 Q3 INFECTIOUS DISEASES

Sexually transmitted diseases Pub Date : 2025-02-17 DOI:10.1097/OLQ.0000000000002138

Ciarra Leocadio, Gabriela Betancourt, Jennifer Tang, Zachary Heth, Preeti Pathela

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引用次数: 0

摘要

摘要：背景：衣原体、淋病和梅毒等细菌性性传播感染的发病率不断上升，因此需要新的预防策略。预防性使用强力霉素就是其中一种策略，事实证明它能有效减少男男性行为者（MSM）和变性女性的传播。我们评估了纽约市（NYC）性健康诊所（SHC）患者对强力霉素暴露前/暴露后预防（doxyPrEP/doxyPEP）的认识、态度和兴趣，这些患者包括男男性行为者、其他顺性别男性、女性、变性人以及性别不符或非二元性患者：2023 年 6 月至 8 月期间，纽约市五家 SHC 的 280 名患者完成了一项自填式调查，该调查收集了评估他们对 doxyPrEP 和 doxyPEP 的了解程度、关注点和使用意愿的信息。我们使用泊松回归模型研究了与使用 doxyPEP 意愿相关的因素：在 280 名患者中，分别有 73% （205 人）和 55% （153 人）表示，如果他们的医疗服务提供者提供 doxyPEP 和 doxyPrEP，他们会服用。在不同性别组别中均可观察到使用 doxyPEP 的意愿，而且这种意愿与是否曾经或正在使用 HIV 暴露前预防疗法有显著关联（调整风险比 (aRR) 1.17，95% CI：1.07-1.27）。与非西班牙裔白人参与者相比，西班牙裔（aRR 1.27，95% CI：1.07-1.52）和非西班牙裔其他群体（阿拉斯加原住民、美国印第安人、夏威夷原住民、太平洋岛民、多种族）（aRR 1.28，95% CI：1.06-1.56）参与者更有可能表示愿意使用强力PEP。可能产生的抗生素耐药性是最令人担忧的问题：结论：如果医疗服务提供者提供强力杀菌剂，那么所有性别群体的患者都可能接受强力杀菌剂。对其他环境下的可接受性进行更多的研究将有助于为广泛实施提供指导。

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Awareness, attitudes, and interest in doxyPEP as bacterial prophylaxis against sexually transmitted infections - New York City Sexual Health Clinics, June-August 2023.

Abstract: Background: Increased incidence of bacterial sexually transmitted infections including chlamydia, gonorrhea, and syphilis dictates the need for novel prevention strategies. One such strategy, doxycycline prescribed prophylactically, has proven to be effective at reducing transmission among men who have sex with men (MSM) and transgender women. We assessed awareness, attitudes, and interest in doxycycline pre-exposure/post-exposure prophylaxis (doxyPrEP/doxyPEP) among New York City (NYC) Sexual Health Clinic (SHC) patients, including MSM, other cisgender men, women, transgender persons, and patients identifying as gender non-conforming or non-binary.Methods: A self-administered survey was completed by 280 patients from five NYC SHCs between June-August 2023 that collected information assessing their knowledge, concerns, and willingness to use doxyPrEP and doxyPEP. We used Poisson regression models to examine factors associated with willingness to use doxyPEP.Results: Of the 280 patients, 73% (205) and 55% (153) reported they would take doxyPEP and doxyPrEP, respectively, if offered by their provider. Willingness to use doxyPEP was observed across gender groups and significantly associated with history or current use of HIV pre-exposure prophylaxis (adjusted risk ratio (aRR) 1.17, 95% CI: 1.07-1.27). Compared to non-Hispanic white participants, Hispanic (aRR 1.27, 95% CI: 1.07-1.52) and Non-Hispanic Other (Alaskan Native, American Indian, Native Hawaiian, Pacific Islander, multiracial) group (aRR 1.28, 95% CI: 1.06-1.56) participants were more likely to report willingness to use doxyPEP. Possible antibiotic resistance was of highest concern.Conclusions: If offered by a provider, doxyPEP would likely be accepted by patients of all gender groups. Additional research on acceptability in other settings would help guide widespread implementation.

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来源期刊

Sexually transmitted diseases 医学-传染病学

CiteScore

4.00

自引率

16.10%

发文量

289

审稿时长

3-8 weeks

期刊介绍： Sexually Transmitted Diseases, the official journal of the American Sexually Transmitted Diseases Association, publishes peer-reviewed, original articles on clinical, laboratory, immunologic, epidemiologic, behavioral, public health, and historical topics pertaining to sexually transmitted diseases and related fields. Reports from the CDC and NIH provide up-to-the-minute information. A highly respected editorial board is composed of prominent scientists who are leaders in this rapidly changing field. Included in each issue are studies and developments from around the world.