会聚功能不全个体的脑结构和功能磁共振成像改变。

IF 2.8 3区 医学 Q1 OPHTHALMOLOGY
Ophthalmic and Physiological Optics Pub Date : 2025-05-01 Epub Date: 2025-02-18 DOI:10.1111/opo.13459
Yuxia Wang, Gantian Huang, Ye Wu, Ling Xiong, Yufei Chen, Haoran Li, Fenghua Long, Qian Li, Huaiqiang Sun, Graham J Kemp, Longqian Liu, Qiyong Gong, Fei Li
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引用次数: 0

摘要

目的:会聚功能不全(CI)的个体在近距离工作时遇到向内转动眼睛的挑战。目前还不清楚这与大脑结构和功能改变之间的关系。本研究旨在利用多模态脑磁共振成像(MRI)技术探讨脑缺血的神经机制。方法:招募34名CI参与者和35名健康对照(HC),进行视觉检查和脑MRI扫描。分析结构MRI数据,计算皮质厚度、体积和表面积。从静息状态功能MRI数据中获得低频波动分数幅值(fALFF)和基于种子的功能连通性。比较两组患者的脑结构和功能指标,并分析临床指标与重要脑特征之间的相关性。结果:与HC相比,CI患者的右侧额野、顶叶野和左侧内侧眶额皮质的灰质体积(GMV)和表面积更低,右侧额中回和颞下回的GMV和表面积更高,左侧小脑的fALFF更高,双侧小脑之间的功能连接也更高。所有参与者的右额中回GMV和左小脑fALFF均与近收敛点呈正相关。结论:视觉和动眼皮层结构指标较低,小脑功能活动较高可能是趋同功能障碍和视觉疲劳的基础,而右侧额叶中回和颞下回结构指标较高反映了对视觉和动眼皮层缺陷的部分补偿,从而维持了注意力和视差信息加工。本研究通过揭示CI的异常视觉体验对大脑的影响,以及在会聚系统中分离的结构和功能改变,可以增强对CI神经机制的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Brain structural and functional magnetic resonance imaging alterations in individuals with convergence insufficiency.

Purpose: Individuals with convergence insufficiency (CI) encounter challenges in turning their eyes inward during near work. It is unclear how this relates to brain structural and functional alterations. This study aimed to explore the neural mechanism underlying CI using multimodal brain magnetic resonance imaging (MRI).

Methods: Thirty-four CI participants and 35 healthy controls (HC) were recruited, who underwent visual examinations and brain MRI scanning. Structural MRI data were analysed to calculate cortical thickness, volume and surface area. Fractional amplitude of low-frequency fluctuation (fALFF) and seed-based functional connectivity were obtained from resting-state functional MRI data. The brain structural and functional metrics were compared between the two groups followed by correlation analyses between clinical measurements and significant brain features.

Results: Relative to HC, individuals with CI had lower grey matter volume (GMV) and surface area in the right frontal eye fields, parietal eye fields and left medial orbitofrontal cortex, higher GMV and surface area in the right middle frontal and inferior temporal gyri and higher fALFF of the left cerebellum and functional connection between bilateral cerebellums. GMV of the right middle frontal gyrus and fALFF in the left cerebellum were positively correlated with the near point of convergence in all participants.

Conclusions: Lower structural metrics in the visual and oculomotor cortices and higher functional activity in the cerebellum may underpin convergence dysfunction and visual fatigue, while higher structural metrics in the right middle frontal and inferior temporal gyri reflect partial compensation for the visual and oculomotor cortex defects, thereby maintaining attention and parallax information processing. This study may enhance understanding of the neural mechanism of CI by revealing the impact of abnormal visual experiences of CI on the brain with disassociated structural and functional alterations in the vergence system.

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来源期刊
CiteScore
5.10
自引率
13.80%
发文量
135
审稿时长
6-12 weeks
期刊介绍: Ophthalmic & Physiological Optics, first published in 1925, is a leading international interdisciplinary journal that addresses basic and applied questions pertinent to contemporary research in vision science and optometry. OPO publishes original research papers, technical notes, reviews and letters and will interest researchers, educators and clinicians concerned with the development, use and restoration of vision.
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