淋巴细胞增强因子-1表达对成人急性早幼粒细胞白血病患者预后的影响。

IF 2.3 4区医学 Q2 HEMATOLOGY

Expert Review of Hematology Pub Date : 2025-01-01 Epub Date: 2025-02-23 DOI:10.1080/17474086.2025.2467870

Thoraya M Abdelhamid, Yasmine Y Hassaneen, Mohamed Ghareeb, Eman O Rasekh

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引用次数: 0

摘要

背景：急性早幼粒细胞白血病（APL）被认为是癌症治疗中最成功的案例之一。然而，早期死亡仍然是治疗失败的主要原因。本研究旨在分析成年apl患者中LEF1的表达，以评估其对生存结局，特别是早期死亡的影响。研究设计与方法：采用RT-qPCR方法分析78例成年APL患者和20例健康匹配供者骨髓样本中LEF1的表达情况。根据受试者工作特性曲线，将LEF1折叠变化的截止值设为0.2250。结果：与对照组相比，apl患者中LEF1表达下调，两组间差异有统计学意义(p >高表达组（p = 0.018）。LEF1被确定为影响早期死亡的独立因素。LEF1低表达的高危患者组总生存率最差。结论：本研究支持LEF1作为APL预后参数和早期死亡预测指标的潜力。将lef1纳入风险分层可能有助于减少早期死亡。未来的研究应探索综合危险因素分析，以改善APL患者的预后。

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The influence of lymphoid enhancer binding factor-1 expression on the outcome of adult acute promyelocytic leukemia patients.

Background: Acute promyelocytic leukemia (APL) is considered one of the greatest success stories in cancer therapy. However, early deaths remain the leading cause of treatment failure. This study aimed to analyze LEF1 expression in adult APL patients to evaluate its impact on survival outcomes, particularly early deaths.

Research design and methods: LEF1 expression was analyzed by RT-qPCR in 78 denovo adult APL samples and 20 bone marrow samples from healthy matched donors as a control group. The cutoff for LEF1 fold change was set at 0.2250 using the receiver operating characteristic curve.

Results: LEF1 expression was down regulated in APL patients as compared to the control group with statistically significant difference between the two groups (p < 0.001). The incidence of early deaths was higher in the low-LEF1 expressers than in high expressers (p = 0.018). LEF1 was determined to be an independent factor affecting early deaths. The high-risk patient group with low LEF1 expression had the worst overall survival.

Conclusions: This study supports the potential of LEF1 to be a prognostic parameter in APL and a predictor of early deaths. Incorporating LEF1 into risk stratification could help to minimize early deaths. Future studies should explore combined risk factor analyses for improved prognosis in APL patients.

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来源期刊

Expert Review of Hematology HEMATOLOGY-

CiteScore

4.70

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Advanced molecular research techniques have transformed hematology in recent years. With improved understanding of hematologic diseases, we now have the opportunity to research and evaluate new biological therapies, new drugs and drug combinations, new treatment schedules and novel approaches including stem cell transplantation. We can also expect proteomics, molecular genetics and biomarker research to facilitate new diagnostic approaches and the identification of appropriate therapies. Further advances in our knowledge regarding the formation and function of blood cells and blood-forming tissues should ensue, and it will be a major challenge for hematologists to adopt these new paradigms and develop integrated strategies to define the best possible patient care. Expert Review of Hematology (1747-4086) puts these advances in context and explores how they will translate directly into clinical practice.