脑肿瘤患者康复后健康相关生活质量的改善不受肿瘤类型的影响。

IF 3.4 3区 医学 Q1 REHABILITATION
Takahiro Watanabe, Shinichi Noto, Manabu Natsumeda, Shinji Kimura, Fumie Ikarashi, Satoshi Tabata, Mayuko Takano, Yoshihiro Tsukamoto, Makoto Oishi
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引用次数: 0

摘要

背景:康复治疗对脑肿瘤患者健康相关生活质量(HRQOL)的影响尚未得到充分研究。目的:应用HRQOL指数评价康复治疗对脑肿瘤患者HRQOL的影响。我们还研究了影响HRQOL变化的因素,包括脑肿瘤类型的差异。设计:前瞻性队列研究。单位:大学医学院和牙科医院。人群:年龄在20岁及以上接受康复治疗的脑肿瘤患者。排除认知能力下降、失语或一般状况较差且难以回答HRQOL问题的患者。方法:采用EuroQol-5维度5-Level (EQ-5D-5L)、EORTC生活质量问卷核心30 (QLQ-C30)、EORTC生活质量问卷脑癌模块(BN20)评估康复治疗前后患者的HRQOL。脑肿瘤类型分为世界卫生组织(WHO) 1级、WHO 2/3级、WHO 4级、原发性中枢神经系统淋巴瘤和转移性脑肿瘤5组。比较康复前后EQ-5D-5L指标评分和QLQ-C30、BN20评分。采用多元回归分析检验EQ-5D-5L指标评分(EQ-5D-5L增益)变化的影响因素。结果:共有112例患者参与本研究。EQ-5D-5L指数中位数由康复前的0.698提高至康复结束时的0.772,差异有统计学意义(P0.3)。多元回归分析显示,复发率(β=-0.191, P=0.037)和基线EQ-5D-5L指数评分(β=-0.595, P)与康复治疗前相比,脑肿瘤患者的HRQOL得到改善。此外,EQ-5D-5L指标评分的增加不受脑肿瘤类型的影响。临床康复影响:这些结果表明康复治疗可能有助于改善HRQOL,而与脑肿瘤类型无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Improved health-related quality of life after rehabilitation in patients with brain tumors is not affected by tumor type.

Background: The effect of rehabilitation therapy on health-related quality of life (HRQOL) among patients with brain tumors has not been fully investigated.

Aim: This study aimed to evaluate the effect of rehabilitation therapy on HRQOL among patients with brain tumors using the HRQOL index. We also examined factors that influenced changes in HRQOL, including differences in brain tumor type.

Design: Prospective cohort study.

Setting: University Medical and Dental Hospital.

Population: Patients with brain tumors aged 20 years or older undergoing rehabilitation therapy were included. Patients with cognitive decline, aphasia, or poor general condition who had difficulty answering HRQOL questions were excluded.

Methods: The EuroQol-5 Dimension 5-Level (EQ-5D-5L), EORTC Quality of Life Questionnaire Core 30 (QLQ-C30), and EORTC Quality of Life Questionnaire Brain Cancer Module (BN20) were used to assess HRQOL before and after rehabilitation treatment. Brain tumor type was classified into five groups: World Health Organization (WHO) grade 1, WHO grade 2/3, WHO grade 4, primary central nervous system lymphoma, and metastatic brain tumor. We compared EQ-5D-5L index scores and QLQ-C30 and BN20 scores before and at the end of rehabilitation. Multiple regression analysis was used to examine factors affecting changes in EQ-5D-5L index score (EQ-5D-5L gain).

Results: In total, 112 patients participated in this study. The median EQ-5D-5L index score significantly improved from 0.698 before rehabilitation to 0.772 at the end of rehabilitation (P<0.001, r=0.46). QLQ-C30 and BN20 scores showed significant improvement in physical functioning, global health status, pain, and motor dysfunction (P<0.001, r>0.3). Multiple regression analysis revealed that recurrence (β=-0.191, P=0.037) and baseline EQ-5D-5L index score (β=-0.595, P<0.001) affected EQ-5D-5L gain, whereas differences in brain tumor type did not.

Conclusions: HRQOL among patients with brain tumors improved at the end of rehabilitation therapy compared with before therapy. Furthermore, the EQ-5D-5L index score gain was not affected by brain tumor type.

Clinical rehabilitation impact: These results suggest rehabilitation therapy may contribute to improved HRQOL irrespective of brain tumor type.

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来源期刊
CiteScore
8.50
自引率
4.40%
发文量
162
审稿时长
6-12 weeks
期刊介绍: The European Journal of Physical and Rehabilitation Medicine publishes papers of clinical interest in physical and rehabilitation medicine.
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