作为暴露生物标志物的脚趾甲中全身氟化物水平及其与墨西哥学童氟斑牙严重程度的关系——一项横断面研究。

IF 2 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biomarkers Pub Date : 2025-03-01 Epub Date: 2025-02-24 DOI:10.1080/1354750X.2025.2456657

Jesús Lavalle-Carrasco, Nelly Molina-Frechero, Elizabeth Hernández-Pérez, Leonor Sánchez-Pérez, Sandra López-Verdín, Ronell Bologna-Molina

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引用次数: 0

摘要

介绍。儿童时期氟化物（F-）暴露过高会导致氟牙症（DF）。钉子已被用于监测与DF有关的全身F-。本研究的目的是评估墨西哥学童脚趾甲中F-水平与DF严重程度的关系。材料和方法。采用Thylstrup和Fejerskov指数（TFI）对来自非流行区（NEAs）和流行区（EAs）的120名学童进行DF筛查。收集脚趾甲以量化全身F-。分析了生物标志物、DF严重程度、自来水摄入量、性别和年龄之间的关系。结果。新生儿和新生儿趾甲中F-的平均值分别为0.63±0.43和2.72±1.38 mg/kg （p = 0.755, 10-11岁的p水平高于8-9岁的p水平）。在来自NEA和EA的墨西哥学童中，脚趾甲中系统性F-水平与DF严重程度相关，这反映了生物标志物准确记录与临床损伤相关的化合物暴露的能力。

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Systemic fluoride levels in toenails as biomarkers of exposure and their association with the severity of dental fluorosis in Mexican schoolchildren - a cross-sectional study.

Introduction: Elevated fluoride (F^-) exposure during childhood produces dental fluorosis (DF). Nails have been used for monitoring systemic F^- in relation to DF. The aim of this study was to evaluate F^- levels in toenails in association with DF severity in Mexican schoolchildren.

Materials and methods: 120 schoolchildren from nonendemic areas (NEAs) and endemic F^- areas (EAs) were screened for DF via the Thylstrup and Fejerskov index (TFI). Toenails were collected to quantify systemic F^-. The associations between the biomarker, DF severity, tap water intake, sex, and age were analyzed.

Results: The mean F^- in toenails in the NEAs and EAs were 0.63 ± 0.43 and 2.72 ± 1.38 mg/kg, respectively (p < 0.001). A positive correlation was observed between the biomarker and DF severity (r_s = 0.755, p < 0.001). Tap water consumption and the biomarker were associated with DF severity (p < 0.001). Within TFI7-8 the mean F^- level was higher in those ages 10-11 than in those ages 8-9 (p < 0.05).

Conclusion: Systemic F^- levels in toenails are associated with DF severity in Mexican schoolchildren from both the NEAs and the EAs, which reflects the ability of the biomarker to accurately record the exposure to the compound in relation to clinical damage.

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来源期刊

Biomarkers 医学-毒理学

CiteScore

5.00

自引率

3.80%

发文量

140

审稿时长

3 months

期刊介绍： The journal Biomarkers brings together all aspects of the rapidly growing field of biomarker research, encompassing their various uses and applications in one essential source. Biomarkers provides a vital forum for the exchange of ideas and concepts in all areas of biomarker research. High quality papers in four main areas are accepted and manuscripts describing novel biomarkers and their subsequent validation are especially encouraged: • Biomarkers of disease • Biomarkers of exposure • Biomarkers of response • Biomarkers of susceptibility Manuscripts can describe biomarkers measured in humans or other animals in vivo or in vitro. Biomarkers will consider publishing negative data from studies of biomarkers of susceptibility in human populations.