Upadacitinib快速治疗肛周克罗恩病。

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY

ACG Case Reports Journal Pub Date : 2025-02-15 eCollection Date: 2025-02-01 DOI:10.14309/crj.0000000000001623

Kristen Brennan, Poonam Beniwal-Patel

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引用次数: 0

摘要

一名20岁的回肠结、狭窄和穿透性克罗恩病（CD）女性患者，尽管接受了转移回肠造口术和ustekinumab药物治疗，但仍出现了新发的肛周和外阴CD。她既往对英夫利昔单抗、维多单抗和阿达木单抗继发性无反应。支持使用药物治疗肛周CD的数据不足。Upadacitinib被批准用于治疗中度至重度活动性溃疡性结肠炎和CD。本病例表明，在开始使用Upadacitinib的几周内，肛周CD成功且快速解决。

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Rapid Resolution of Perianal Crohn's Disease with Upadacitinib.

A 20-year-old woman with ileocolonic, stricturing, and penetrating Crohn's disease (CD) presented with new onset perianal and vulvar CD despite having a diverting ileostomy and medical therapy with ustekinumab. She had previous secondary nonresponse to infliximab, vedolizumab, and adalimumab. There is a paucity of data supporting the use of medical therapies for perianal CD. Upadacitinib is approved for treatment of moderate to severely active ulcerative colitis and CD. This case demonstrates successful and rapid resolution of perianal CD within weeks of initiating upadacitinib.

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来源期刊

ACG Case Reports Journal GASTROENTEROLOGY & HEPATOLOGY-

自引率

14.30%

发文量

170

审稿时长

12 weeks

期刊介绍： ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.