肝硬化患者的膝关节伸展强度和干预措施的影响：系统回顾和荟萃分析。

IF 1.3 4区医学 Q4 GASTROENTEROLOGY & HEPATOLOGY

Acta gastro-enterologica Belgica Pub Date : 2025-01-01 DOI:10.51821/88.1.13033

A Couret, F Rannou, B Pereira, M Duclos, S Mazeaud, J A King, A Abergel, G Ennequin

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引用次数: 0

摘要

背景：肌肉减少症在肝硬化患者中很常见，下肢肌力可能是发病的一个因素。对肝硬化患者的膝关节伸展肌力进行了系统回顾和荟萃分析。方法：检索电子数据库中自成立至2023年3月的文献。两名独立研究人员应用纳入标准评估文章的合格性。在检索到的28篇文章中；其中21人符合资格要求。结果：肝硬化患者与年龄匹配对照组相比，肌肉力量受损（标准化平均差，SMD: 3.48, 95% CI 2.35-4.61, I²= 96.5%）。结论：肝硬化对膝关节伸展力量的负面影响随着疾病的严重程度而加剧。移植导致膝关节伸展力受损。相反，运动训练往往是有益的，使移植前后的康复成为防止肌肉质量和力量损失的一种有吸引力的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Knee extension strength in patients with liver cirrhosis and the impact of interventions: systematic review and meta-analysis.

Background: Sarcopenia is common in patients with cirrhosis and lower limb muscle strength could represent a factor of morbidity. A systematic review with meta-analysis on knee extension muscle strength in patients with cirrhosis was performed.

Methods: Literature was reviewed in electronic databases from inception until March 2023. Two independent researchers applied the inclusion criteria to assess the eligibility of articles. Of the 28 retrieved articles; 21 of them met the eligibility requirements.

Results: Muscle strength was impaired in patients with cirrhosis versus age-matched control (standardized mean difference, SMD: 3.48, 95% CI 2.35-4.61, I² = 96.5%, p<0.001) and was negatively influenced by increasing disease severity, with Child-Pugh A and B superior to C (SMD: 2.62, 95% CI 0.54-4.71, p<0.014; SMD 0.71, 95% CI 0.29-1.13, p<0.001, respectively). Exercise training tended to increase (SMD: 1.21, 95% CI 0.16-2.59, p=0.085), while liver transplantation decreased knee extension strength (SMD: -0.45, 95% CI -0.88 -0.01, p=0.045).

Conclusion: The negative impact of liver cirrhosis on knee extension strength is worsened by the severity of the disease. Transplantation leads to impaired knee extension strength. Conversely, exercise training tends to be beneficial, making rehabilitation pre and post-transplantation an attractive strategy to prevent muscle mass and strength loss.

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来源期刊

Acta gastro-enterologica Belgica Medicine-Gastroenterology

CiteScore

2.30

自引率

20.00%

发文量

期刊介绍： The Journal Acta Gastro-Enterologica Belgica principally publishes peer-reviewed original manuscripts, reviews, letters to editors, book reviews and guidelines in the field of clinical Gastroenterology and Hepatology, including digestive oncology, digestive pathology, as well as nutrition. Pure animal or in vitro work will not be considered for publication in the Journal. Translational research papers (including sections of animal or in vitro work) are considered by the Journal if they have a clear relationship to or relevance for clinical hepato-gastroenterology (screening, disease mechanisms and/or new therapies). Case reports and clinical images will be accepted if they represent an important contribution to the description, the pathogenesis or the treatment of a specific gastroenterology or liver problem. The language of the Journal is English. Papers from any country will be considered for publication. Manuscripts submitted to the Journal should not have been published previously (in English or any other language), nor should they be under consideration for publication elsewhere. Unsolicited papers are peer-reviewed before it is decided whether they should be accepted, rejected, or returned for revision. Manuscripts that do not meet the presentation criteria (as indicated below) will be returned to the authors. Papers that go too far beyond the scope of the journal will be also returned to the authors by the editorial board generally within 2 weeks. The Journal reserves the right to edit the language of papers accepted for publication for clarity and correctness, and to make formal changes to ensure compliance with AGEB’s style. Authors have the opportunity to review such changes in the proofs.