模块化钯催化1,3偶极环加成羰基化合成吡啶[2,1-α]异吲哚的设计

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-02-11 DOI:10.1039/d4cc06483f

Karina S. Wong , Mohammad Ghanbari , Bruce A. Arndtsen

引用次数: 0

摘要

本文报道了一种钯催化的多组分吡啶[2,1-α]异吲哚的合成方法，通过亚胺和2-溴吡啶羰基偶极体形成介离子偶极体，然后与原位生成的芳烃进行环加成。这种一锅方法允许高效，模块化组装多取代产品与独立控制每个构建块。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Design of a modular, palladium-catalyzed carbonylative synthesis of pyrido[2,1-α]isoindoles via benzyne 1,3-dipolar cycloaddition†

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Design of a modular, palladium-catalyzed carbonylative synthesis of pyrido[2,1-α]isoindoles via benzyne 1,3-dipolar cycloaddition†

We report a palladium catalyzed, multicomponent synthesis of pyrido[2,1-α]isoindoles via carbonylative coupling of imines and 2-bromopyridines to form mesoionic dipoles, followed by cycloaddition with in situ generated arynes. This one-pot method allows efficient, modular assembly of polysubstituted products with independent control of each building block.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.