Electrochemical sensing of metoclopramide using a green-synthesised reduced graphene oxide and poly(3-methylthiophene)-modified glassy carbon electrode

This paper describes an eco-friendly green synthesis approach that utilises tangerine peel extracts to generate reduced graphene oxide (rGO). This rGO was employed for the selective and sensitive electrochemical detection of metoclopramide (MCP) on rGO/poly(3-methylthiophene) (rGO/P3MT)-modified glassy carbon electrode (modified GCE) surface using techniques like cyclic voltammetry (CV) and square-wave voltammetry (SWV). The researchers further employed the Raman and Fourier transform infrared (FTIR) spectroscopy to investigate the morphology of compounds deposited on the GCE surface. The researchers studied the influence of different parameters on MCP oxidation behaviour in addition to the oxidation process of MCP on the rGO/P3MT-modified GCE surface. The results of the CV analysis revealed that rGO-modified GCE displayed a high current response owing to its improved catalytic activity in comparison to the pure GCE and showed a detection limit of 0.048 mM. Furthermore, the fabricated rGO/P3MT-modified GCE demonstrated improved stability and consistency. The modified GCE can accurately detect trace MCP concentrations in pure and pharmaceutical formulations.