{"title":"ikelos评定量表：快速眼动睡眠行为障碍行为严重程度标记的验证。","authors":"Sophia Stotz, Frederik Bes, Dieter Kunz","doi":"10.1111/jsr.70019","DOIUrl":null,"url":null,"abstract":"<p><p>The Ikelos-Rating Scale (Ikelos-RS) is a new, expert-interviewed and bedpartner-reported severity marker assessing frequency and expression of isolated REM sleep behaviour disorder (iRBD), a precursor of clinical α-synucleinopathies. This study aimed to validate the Ikelos-RS in 180 patients with three-night PSG-confirmed iRBD (68.4 ± 8.3 years; 139 m). Inter-rater (n = 45) and test-retest reliabilities (n = 25; 174 Ikelos-RS) were evaluated. For construct validity, correlation analyses were performed with: (1) Clinical Global Impressions-Severity (CGI-S; n = 151), (2) REM sleep without atonia (RWA) within videometry (n = 20), (3) RWA at initial diagnosis (n = 131) and changes over time (n = 36), (4) dopamine transporter scintigraphy (DaT-SPECT) at baseline and changes over time (n = 75). RWA- and DaT-SPECT-analyses were conducted for the whole sample ('all') and after excluding confounders ('cleaned'). Correlation analyses indicated high inter-rater (r<sub>s</sub> = 0.865, p < 0.001) and test-retest reliabilities (r<sub>s</sub> = 0.900, p < 0.001). Construct validity was supported by associations of Ikelos-RS with (1) CGI-S (r<sub>s</sub> = 0.845, p < 0.001), (2) RWA within videometric analysis (r<sub>s</sub> = 0.592, p = 0.006) and at baseline ('all': r<sub>s</sub> = 0.274, p = 0.002), (3) DaT-binding (z-scores) at baseline in right anterior putamen (AP) ('all': r<sub>s</sub> = -0.319, p = 0.005) and changes over time, most pronounced in right anterior putamen (AP) ('all': r<sub>s</sub> = -0.243, p = 0.035; 'cleaned': r<sub>s</sub> = -0.374, p = 0.008) and left posterior putamen (PP) ('all': r<sub>s</sub> = -0.259, p = 0.025; 'cleaned': r<sub>s</sub> = -0.319, p = 0.024). Given its high reliability and construct validity, demonstrated by associations with the best available severity markers DaT-binding ratios and RWA, Ikelos-RS appears to represent a reliable, valid and easy-to-use tool for measuring the severity of iRBD. Thus, Ikelos-RS may prove beneficial in research. Its suitability as a screening tool in older at-risk populations needs to be proven in future studies.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70019"},"PeriodicalIF":3.4000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ikelos-Rating Scale: Validation of a Behavioural Severity Marker in REM Sleep Behaviour Disorder.\",\"authors\":\"Sophia Stotz, Frederik Bes, Dieter Kunz\",\"doi\":\"10.1111/jsr.70019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The Ikelos-Rating Scale (Ikelos-RS) is a new, expert-interviewed and bedpartner-reported severity marker assessing frequency and expression of isolated REM sleep behaviour disorder (iRBD), a precursor of clinical α-synucleinopathies. This study aimed to validate the Ikelos-RS in 180 patients with three-night PSG-confirmed iRBD (68.4 ± 8.3 years; 139 m). Inter-rater (n = 45) and test-retest reliabilities (n = 25; 174 Ikelos-RS) were evaluated. For construct validity, correlation analyses were performed with: (1) Clinical Global Impressions-Severity (CGI-S; n = 151), (2) REM sleep without atonia (RWA) within videometry (n = 20), (3) RWA at initial diagnosis (n = 131) and changes over time (n = 36), (4) dopamine transporter scintigraphy (DaT-SPECT) at baseline and changes over time (n = 75). RWA- and DaT-SPECT-analyses were conducted for the whole sample ('all') and after excluding confounders ('cleaned'). Correlation analyses indicated high inter-rater (r<sub>s</sub> = 0.865, p < 0.001) and test-retest reliabilities (r<sub>s</sub> = 0.900, p < 0.001). Construct validity was supported by associations of Ikelos-RS with (1) CGI-S (r<sub>s</sub> = 0.845, p < 0.001), (2) RWA within videometric analysis (r<sub>s</sub> = 0.592, p = 0.006) and at baseline ('all': r<sub>s</sub> = 0.274, p = 0.002), (3) DaT-binding (z-scores) at baseline in right anterior putamen (AP) ('all': r<sub>s</sub> = -0.319, p = 0.005) and changes over time, most pronounced in right anterior putamen (AP) ('all': r<sub>s</sub> = -0.243, p = 0.035; 'cleaned': r<sub>s</sub> = -0.374, p = 0.008) and left posterior putamen (PP) ('all': r<sub>s</sub> = -0.259, p = 0.025; 'cleaned': r<sub>s</sub> = -0.319, p = 0.024). Given its high reliability and construct validity, demonstrated by associations with the best available severity markers DaT-binding ratios and RWA, Ikelos-RS appears to represent a reliable, valid and easy-to-use tool for measuring the severity of iRBD. Thus, Ikelos-RS may prove beneficial in research. Its suitability as a screening tool in older at-risk populations needs to be proven in future studies.</p>\",\"PeriodicalId\":17057,\"journal\":{\"name\":\"Journal of Sleep Research\",\"volume\":\" \",\"pages\":\"e70019\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-02-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Sleep Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/jsr.70019\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Sleep Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/jsr.70019","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
摘要
ikelos评分量表（Ikelos-RS）是一种新的、专家访谈和床伴报告的严重程度标记物，用于评估孤立性快速眼动睡眠行为障碍（iRBD）的频率和表达，iRBD是临床α-突触核蛋白病的前兆。本研究旨在验证180例三晚psg证实的iRBD患者的Ikelos-RS(68.4±8.3年；139米)。测验间信度（n = 45）和重测信度(n = 25；174个Ikelos-RS)进行评估。对于结构效度，进行相关分析：(1)临床总体印象-严重程度（CGI-S）；n = 151),(2)视频测量中无张力的快速眼动睡眠（RWA） （n = 20），(3)初始诊断时的RWA （n = 131）及其随时间变化（n = 36），(4)基线时多巴胺转运体闪烁图（dc - spect）及其随时间变化（n = 75）。对整个样本（“全部”）和排除混杂因素（“清理”）后进行RWA-和dat - spect分析。相关分析显示，基线时（'all': rs = 0.274, p = 0.002）和基线时（'all': rs = -0.319, p = 0.005），右侧前壳核（AP）的基线时（'all': rs = -0.243, p = 0.035）的间率较高（rs = 0.865, p = 0.900, p = 0.845, p = 0.592, p = 0.006）；“清洗”:rs = -0.374, p = 0.008)和左后壳(PP)(“所有”:rs = -0.259, p = 0.025;‘cleaned’： rs = -0.319, p = 0.024)。Ikelos-RS具有较高的可靠性和结构效度，并与最佳的严重程度标记物dat结合率和RWA相关联，因此Ikelos-RS似乎是一种可靠、有效和易于使用的测量iRBD严重程度的工具。因此，Ikelos-RS可能在研究中被证明是有益的。它作为一种筛查工具在老年高危人群中的适用性需要在未来的研究中得到证实。
Ikelos-Rating Scale: Validation of a Behavioural Severity Marker in REM Sleep Behaviour Disorder.
The Ikelos-Rating Scale (Ikelos-RS) is a new, expert-interviewed and bedpartner-reported severity marker assessing frequency and expression of isolated REM sleep behaviour disorder (iRBD), a precursor of clinical α-synucleinopathies. This study aimed to validate the Ikelos-RS in 180 patients with three-night PSG-confirmed iRBD (68.4 ± 8.3 years; 139 m). Inter-rater (n = 45) and test-retest reliabilities (n = 25; 174 Ikelos-RS) were evaluated. For construct validity, correlation analyses were performed with: (1) Clinical Global Impressions-Severity (CGI-S; n = 151), (2) REM sleep without atonia (RWA) within videometry (n = 20), (3) RWA at initial diagnosis (n = 131) and changes over time (n = 36), (4) dopamine transporter scintigraphy (DaT-SPECT) at baseline and changes over time (n = 75). RWA- and DaT-SPECT-analyses were conducted for the whole sample ('all') and after excluding confounders ('cleaned'). Correlation analyses indicated high inter-rater (rs = 0.865, p < 0.001) and test-retest reliabilities (rs = 0.900, p < 0.001). Construct validity was supported by associations of Ikelos-RS with (1) CGI-S (rs = 0.845, p < 0.001), (2) RWA within videometric analysis (rs = 0.592, p = 0.006) and at baseline ('all': rs = 0.274, p = 0.002), (3) DaT-binding (z-scores) at baseline in right anterior putamen (AP) ('all': rs = -0.319, p = 0.005) and changes over time, most pronounced in right anterior putamen (AP) ('all': rs = -0.243, p = 0.035; 'cleaned': rs = -0.374, p = 0.008) and left posterior putamen (PP) ('all': rs = -0.259, p = 0.025; 'cleaned': rs = -0.319, p = 0.024). Given its high reliability and construct validity, demonstrated by associations with the best available severity markers DaT-binding ratios and RWA, Ikelos-RS appears to represent a reliable, valid and easy-to-use tool for measuring the severity of iRBD. Thus, Ikelos-RS may prove beneficial in research. Its suitability as a screening tool in older at-risk populations needs to be proven in future studies.
期刊介绍：
The Journal of Sleep Research is dedicated to basic and clinical sleep research. The Journal publishes original research papers and invited reviews in all areas of sleep research (including biological rhythms). The Journal aims to promote the exchange of ideas between basic and clinical sleep researchers coming from a wide range of backgrounds and disciplines. The Journal will achieve this by publishing papers which use multidisciplinary and novel approaches to answer important questions about sleep, as well as its disorders and the treatment thereof.
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