Leslie Zhi Wei Lew, Benjamin M Mac Curtain, Teck Siew, Zi Qin Ng
{"title":"FDG PET-CT在局部直肠癌中的预测作用：一项系统综述和荟萃分析。","authors":"Leslie Zhi Wei Lew, Benjamin M Mac Curtain, Teck Siew, Zi Qin Ng","doi":"10.1111/1754-9485.13841","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Rectal carcinoma (RC) has high incidence and rate of recurrence. Currently, routine 18- fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET-CT) is not recommend for routine monitoring for post RC treatment. We examined the utility of FDG PET-CT for the prognostication of patients with RC and what FDG PET-CT metrics are of value.</p><p><strong>Methods: </strong>PubMed, Embase, MEDLINE, and Cochrane (Central) were comprehensively searched till 19 May 2024. A modified Newcastle Ottawa scale was used to assess for study bias. We presented our systematic review alongside pooled hazard ratios (HR) for maximum standardised uptake values (SUV) as a predictor of disease-free survival (DFS) and overall survival (OS).</p><p><strong>Results: </strong>Eleven papers including 771 patients were included in our systematic review. Considering the current evidence, there is potential to consider percentage change in SUV<sub>max</sub>, TLG, MTV, and lymph node highest peak SUV as possible predictors of outcome for localised non metastatic rectal carcinoma.</p><p><strong>Conclusions: </strong>Pooled meta-analysis of three homogenous parameters examines the relationship of SUV<sub>Max</sub> and survival, and did not demonstrate correlation with survival outcomes. The overall pooled hazard ratio for pretreatment SUV<sub>Max</sub> to DFS was 0.69, CI (0.29-1.63). The overall pooled HR for post treatment SUV<sub>Max</sub> to DFS was 0.88, CI (0.43-1.81), and posttreatment SUV<sub>Max</sub> to OS was 1.73, CI (0.34-8.66). Post treatment FDG PET-CT may have a role to play in the prognostic evaluation of RC patients; however, further data is required.</p>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":" ","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Predictive Role of FDG PET-CT in Localised Rectal Carcinoma: A Systematic Review and Meta-Analysis.\",\"authors\":\"Leslie Zhi Wei Lew, Benjamin M Mac Curtain, Teck Siew, Zi Qin Ng\",\"doi\":\"10.1111/1754-9485.13841\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Rectal carcinoma (RC) has high incidence and rate of recurrence. Currently, routine 18- fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET-CT) is not recommend for routine monitoring for post RC treatment. We examined the utility of FDG PET-CT for the prognostication of patients with RC and what FDG PET-CT metrics are of value.</p><p><strong>Methods: </strong>PubMed, Embase, MEDLINE, and Cochrane (Central) were comprehensively searched till 19 May 2024. A modified Newcastle Ottawa scale was used to assess for study bias. We presented our systematic review alongside pooled hazard ratios (HR) for maximum standardised uptake values (SUV) as a predictor of disease-free survival (DFS) and overall survival (OS).</p><p><strong>Results: </strong>Eleven papers including 771 patients were included in our systematic review. Considering the current evidence, there is potential to consider percentage change in SUV<sub>max</sub>, TLG, MTV, and lymph node highest peak SUV as possible predictors of outcome for localised non metastatic rectal carcinoma.</p><p><strong>Conclusions: </strong>Pooled meta-analysis of three homogenous parameters examines the relationship of SUV<sub>Max</sub> and survival, and did not demonstrate correlation with survival outcomes. The overall pooled hazard ratio for pretreatment SUV<sub>Max</sub> to DFS was 0.69, CI (0.29-1.63). The overall pooled HR for post treatment SUV<sub>Max</sub> to DFS was 0.88, CI (0.43-1.81), and posttreatment SUV<sub>Max</sub> to OS was 1.73, CI (0.34-8.66). Post treatment FDG PET-CT may have a role to play in the prognostic evaluation of RC patients; however, further data is required.</p>\",\"PeriodicalId\":16218,\"journal\":{\"name\":\"Journal of Medical Imaging and Radiation Oncology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-02-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Medical Imaging and Radiation Oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/1754-9485.13841\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Imaging and Radiation Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/1754-9485.13841","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Predictive Role of FDG PET-CT in Localised Rectal Carcinoma: A Systematic Review and Meta-Analysis.
Introduction: Rectal carcinoma (RC) has high incidence and rate of recurrence. Currently, routine 18- fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET-CT) is not recommend for routine monitoring for post RC treatment. We examined the utility of FDG PET-CT for the prognostication of patients with RC and what FDG PET-CT metrics are of value.
Methods: PubMed, Embase, MEDLINE, and Cochrane (Central) were comprehensively searched till 19 May 2024. A modified Newcastle Ottawa scale was used to assess for study bias. We presented our systematic review alongside pooled hazard ratios (HR) for maximum standardised uptake values (SUV) as a predictor of disease-free survival (DFS) and overall survival (OS).
Results: Eleven papers including 771 patients were included in our systematic review. Considering the current evidence, there is potential to consider percentage change in SUVmax, TLG, MTV, and lymph node highest peak SUV as possible predictors of outcome for localised non metastatic rectal carcinoma.
Conclusions: Pooled meta-analysis of three homogenous parameters examines the relationship of SUVMax and survival, and did not demonstrate correlation with survival outcomes. The overall pooled hazard ratio for pretreatment SUVMax to DFS was 0.69, CI (0.29-1.63). The overall pooled HR for post treatment SUVMax to DFS was 0.88, CI (0.43-1.81), and posttreatment SUVMax to OS was 1.73, CI (0.34-8.66). Post treatment FDG PET-CT may have a role to play in the prognostic evaluation of RC patients; however, further data is required.
期刊介绍：
Journal of Medical Imaging and Radiation Oncology (formerly Australasian Radiology) is the official journal of The Royal Australian and New Zealand College of Radiologists, publishing articles of scientific excellence in radiology and radiation oncology. Manuscripts are judged on the basis of their contribution of original data and ideas or interpretation. All articles are peer reviewed.
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