肠病毒与I型干扰素相互作用下手足口病的潜在治疗物质

IF 4.9 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Antimicrobial Agents Pub Date : 2025-02-15 DOI:10.1016/j.ijantimicag.2025.107464

Xinyu Wang , Ziyuan Wang , Zhongtian Qi , Yongzhe Zhu

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引用次数: 0

摘要

手足口病（HFMD）在世界范围内广泛传播。严重的手足口病可导致肺炎、脑炎、心肌炎、横贯脊髓炎等并发症，甚至死亡。由于手足口病是由至少20种肠道病毒引起的，因此迫切需要广谱抗病毒药物来帮助控制手足口病疫情的传播。I型干扰素（Type I interferon， IFN）作为免疫应答中不可缺少的一部分，在抑制肠道病毒无物种特异性的复制周期，以及通过诱导IFN刺激基因的激活来调节先天免疫系统方面发挥着关键作用。本文系统总结了肠病毒与I型IFN的相互作用，包括I型IFN的激活和逃避途径。此外，我们还提出了具有治疗潜力的抗肠病毒药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Potential therapeutic substances for hand-foot-and-mouth disease in the interplay of enteroviruses and type I interferon

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Potential therapeutic substances for hand-foot-and-mouth disease in the interplay of enteroviruses and type I interferon

Objectives

Hand-foot-and-mouth disease (HFMD) is widespread in the world. Severe HFMD can lead to complications like pneumonia, encephalitis, myocarditis, transverse myelitis and even death. Since HFMD is caused by at least 20 types of enteroviruses, there is an urgent need for broad-spectrum antiviral drugs to help control the spread of HFMD outbreaks.

Methods

Type I interferon (IFN), as an indispensable part of the immune response, plays a key role in the inhibition of the enterovirus replication cycle without species specificity, and regulation of the innate immune system by inducing the activation of the IFN-stimulated genes.

Conclusions

Here, the interplay of enteroviruses and type I IFN was systematically summarized, including pathways for the activation and evasion of type I IFN. Besides, we proposed promising anti-enterovirus agents with therapeutic potential.

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来源期刊

International Journal of Antimicrobial Agents 医学-传染病学

CiteScore

21.60

自引率

0.90%

发文量

176

审稿时长

36 days

期刊介绍： The International Journal of Antimicrobial Agents is a peer-reviewed publication offering comprehensive and current reference information on the physical, pharmacological, in vitro, and clinical properties of individual antimicrobial agents, covering antiviral, antiparasitic, antibacterial, and antifungal agents. The journal not only communicates new trends and developments through authoritative review articles but also addresses the critical issue of antimicrobial resistance, both in hospital and community settings. Published content includes solicited reviews by leading experts and high-quality original research papers in the specified fields.