免疫功能低下人群中与COVID-19感染相关的隔离预防措施：9个国家癌症研究所指定的综合癌症中心的多中心研究

IF 3.8 3区医学 Q2 INFECTIOUS DISEASES

American journal of infection control Pub Date : 2025-02-14 DOI:10.1016/j.ajic.2025.02.002

Marie H. Wilson MSN, RN, CIC, FAPIC , Jennifer Harrington MA, CIC , Joanna Suh MPH, CIC , Candice Fearon MSGH, BSN, RN, CIC , Maggie Reavis MPH, BSN, RN, CIC, CPHQ , Suwannee Srisatidnarakul MSN, RN, CIC , Michelle Swetky MPH, CIC, FAPIC , Nancy Warren MHA, MLT(ASCP), CIC , Angela Badalucco MPH, MT(ASCP) , Caitlin M. Adams Barker MSN, RN, CIC, FAPIC , Shobana Nandakumar MHA, M(ASCP), CQPA , Steven A. Pergam MD, MPH

{"title":"免疫功能低下人群中与COVID-19感染相关的隔离预防措施：9个国家癌症研究所指定的综合癌症中心的多中心研究","authors":"Marie H. Wilson MSN, RN, CIC, FAPIC , Jennifer Harrington MA, CIC , Joanna Suh MPH, CIC , Candice Fearon MSGH, BSN, RN, CIC , Maggie Reavis MPH, BSN, RN, CIC, CPHQ , Suwannee Srisatidnarakul MSN, RN, CIC , Michelle Swetky MPH, CIC, FAPIC , Nancy Warren MHA, MLT(ASCP), CIC , Angela Badalucco MPH, MT(ASCP) , Caitlin M. Adams Barker MSN, RN, CIC, FAPIC , Shobana Nandakumar MHA, M(ASCP), CQPA , Steven A. Pergam MD, MPH","doi":"10.1016/j.ajic.2025.02.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Nine Comprehensive Cancer Centers sought to understand COVID-19 infection management experiences to improve future immunocompromised host guidelines.</div></div><div><h3>Methods</h3><div>Volunteers from Comprehensive Cancer Center Infection Prevention and Control (C3IC) completed 2 surveys on COVID-19 practices from March 2020 to December 2023. Three reviewers independently validated qualitative analysis of findings. Virtual meetings were leveraged to discuss findings and identify themes.</div></div><div><h3>Results</h3><div>100% (9/9) of respondents changed COVID-19-associated isolation discontinuation guidance at least once. All (9/9) included patient immune status as criterion. All (9/9) required clearance testing at some point in the pandemic, 6 of 9 (66%) continued to require clearance testing at the time of the survey. Only 1 of 9 (11%) allowed antigen testing to meet criteria. Seven isolation titles were noted across 9 institutions, despite near agreement on measures employed.</div></div><div><h3>Discussion</h3><div>Variability existed in COVID-19 management among study participants, despite serving similar populations, which may stem from limited data supporting understanding of viral transmissibility in immunocompromised hosts.</div></div><div><h3>Conclusions</h3><div>Guideline development for immunocompromised hosts, potential drivers for viral evolution, can lack clarity for consistent management of the population. Engaging subject matters in specialty populations with future guideline development will improve infection prevention in health care settings.</div></div>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":"53 5","pages":"Pages 596-601"},"PeriodicalIF":3.8000,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Isolation precautions associated with COVID-19 infections among immunocompromised populations: A multicenter study of nine National Cancer Institute--designated Comprehensive Cancer Centers\",\"authors\":\"Marie H. Wilson MSN, RN, CIC, FAPIC , Jennifer Harrington MA, CIC , Joanna Suh MPH, CIC , Candice Fearon MSGH, BSN, RN, CIC , Maggie Reavis MPH, BSN, RN, CIC, CPHQ , Suwannee Srisatidnarakul MSN, RN, CIC , Michelle Swetky MPH, CIC, FAPIC , Nancy Warren MHA, MLT(ASCP), CIC , Angela Badalucco MPH, MT(ASCP) , Caitlin M. Adams Barker MSN, RN, CIC, FAPIC , Shobana Nandakumar MHA, M(ASCP), CQPA , Steven A. Pergam MD, MPH\",\"doi\":\"10.1016/j.ajic.2025.02.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Nine Comprehensive Cancer Centers sought to understand COVID-19 infection management experiences to improve future immunocompromised host guidelines.</div></div><div><h3>Methods</h3><div>Volunteers from Comprehensive Cancer Center Infection Prevention and Control (C3IC) completed 2 surveys on COVID-19 practices from March 2020 to December 2023. Three reviewers independently validated qualitative analysis of findings. Virtual meetings were leveraged to discuss findings and identify themes.</div></div><div><h3>Results</h3><div>100% (9/9) of respondents changed COVID-19-associated isolation discontinuation guidance at least once. All (9/9) included patient immune status as criterion. All (9/9) required clearance testing at some point in the pandemic, 6 of 9 (66%) continued to require clearance testing at the time of the survey. Only 1 of 9 (11%) allowed antigen testing to meet criteria. Seven isolation titles were noted across 9 institutions, despite near agreement on measures employed.</div></div><div><h3>Discussion</h3><div>Variability existed in COVID-19 management among study participants, despite serving similar populations, which may stem from limited data supporting understanding of viral transmissibility in immunocompromised hosts.</div></div><div><h3>Conclusions</h3><div>Guideline development for immunocompromised hosts, potential drivers for viral evolution, can lack clarity for consistent management of the population. Engaging subject matters in specialty populations with future guideline development will improve infection prevention in health care settings.</div></div>\",\"PeriodicalId\":7621,\"journal\":{\"name\":\"American journal of infection control\",\"volume\":\"53 5\",\"pages\":\"Pages 596-601\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-02-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of infection control\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0196655325000550\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of infection control","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0196655325000550","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

摘要

背景：9个综合癌症中心试图通过大流行了解COVID-19感染管理经验，以改善未来免疫功能低下宿主指南的制定。方法：2020年3月至2023年12月，来自癌症综合感染预防控制中心（C3IC）的志愿者完成了两次COVID-19实践调查。三位审稿人独立验证了结果的定性分析。利用虚拟会议来审查收集到的信息，讨论调查结果，并确定受访者的主题。结果：100%（9/9）的受访者至少修改了一次与covid -19相关的隔离停止指南。所有（9/9）均以患者免疫状态为标准。所有（9/9）在大流行的某个时候都需要进行PCR清除检测，9个中有6个（66%）在调查时仍然需要进行清除检测；只有1 / 9（11%）允许抗原检测符合标准。周期阈值（CT）的引用不一致，被认为与隔离管理有关。尽管对所采取的措施几乎一致，但在9个机构中发现了7个隔离名称。讨论：尽管服务于相似的人群，但研究参与者在COVID-19管理方面存在差异，这可能源于有限的数据支持对免疫功能低下宿主中病毒传播性的理解。结论：针对免疫功能低下宿主（病毒进化的潜在驱动因素）的指南制定可能缺乏对人群一致管理的明确性。在未来的指南制定中，涉及这些人群的主题将改善卫生保健机构的感染预防。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Isolation precautions associated with COVID-19 infections among immunocompromised populations: A multicenter study of nine National Cancer Institute--designated Comprehensive Cancer Centers

Background

Nine Comprehensive Cancer Centers sought to understand COVID-19 infection management experiences to improve future immunocompromised host guidelines.

Methods

Volunteers from Comprehensive Cancer Center Infection Prevention and Control (C3IC) completed 2 surveys on COVID-19 practices from March 2020 to December 2023. Three reviewers independently validated qualitative analysis of findings. Virtual meetings were leveraged to discuss findings and identify themes.

Results

100% (9/9) of respondents changed COVID-19-associated isolation discontinuation guidance at least once. All (9/9) included patient immune status as criterion. All (9/9) required clearance testing at some point in the pandemic, 6 of 9 (66%) continued to require clearance testing at the time of the survey. Only 1 of 9 (11%) allowed antigen testing to meet criteria. Seven isolation titles were noted across 9 institutions, despite near agreement on measures employed.

Discussion

Variability existed in COVID-19 management among study participants, despite serving similar populations, which may stem from limited data supporting understanding of viral transmissibility in immunocompromised hosts.

Conclusions

Guideline development for immunocompromised hosts, potential drivers for viral evolution, can lack clarity for consistent management of the population. Engaging subject matters in specialty populations with future guideline development will improve infection prevention in health care settings.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

American journal of infection control 医学-传染病学

CiteScore

7.40

自引率

4.10%

发文量

479

审稿时长

24 days

期刊介绍： AJIC covers key topics and issues in infection control and epidemiology. Infection control professionals, including physicians, nurses, and epidemiologists, rely on AJIC for peer-reviewed articles covering clinical topics as well as original research. As the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC)