使用模板化动态共价聚合物输送 mRNA。

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-02-17 DOI:10.1039/d4cc06518b

José García Coll, Lamiaa M A Ali, Javier Montenegro, Nadir Bettache, Sébastien Ulrich

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mRNA delivery with templated dynamic covalent polymers.

Messenger RNA is a novel therapeutic modality which was key in curbing the Covid-19 pandemic. However, the delivery of mRNA in cells requires the development of smart vectors. We here report on amphiphilic dynamic covalent polymers formed in situ through RNA templating, and show effective nanoparticle formation and delivery of EGFP mRNA in cells.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.