封面专题：酶还原肼合成取代无环和环n -烷基肼（ChemBioChem 4/2025）

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

ChemBioChem Pub Date : 2025-02-18 DOI:10.1002/cbic.202580402

Niels Borlinghaus, Donato Calabrese, Lars Lauterbach, Bettina M. Nestl

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引用次数: 0

摘要

来自粘球菌stipitatus的亚胺还原酶（IRED）催化结构多样的羰基和二羰基与肼（还原性肼化）的还原胺化，也被称为火箭燃料。这种高效的工艺生产无环和环n -烷基肼，证明了ired在以H₂作为还原剂的可持续“绿色”化学合成中的可扩展性和潜力。更多信息可以在10.1002/cbic文章中找到。Lars Lauterbach, Bettina M. nestle及其同事的202400700。Lutz插图Kupferschläger。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cover Feature: Synthesis of Substituted Acyclic and Cyclic N-Alkylhydrazines by Enzymatic Reductive Hydrazinations (ChemBioChem 4/2025)

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Cover Feature: Synthesis of Substituted Acyclic and Cyclic N-Alkylhydrazines by Enzymatic Reductive Hydrazinations (ChemBioChem 4/2025)

The imine reductase (IRED) from Myxococcus stipitatus catalyses the reductive amination of structurally diverse carbonyls and dicarbonyls with hydrazines (reductive hydrazination), which are also known as rocket fuels. This efficient process produces acyclic and cyclic N-alkylhydrazines, demonstrating the scalability and potential of IREDs for sustainable ′green′ chemical synthesis using H₂ as the reducing agent. More information can be found in the article 10.1002/cbic.202400700 by Lars Lauterbach, Bettina M. Nestl and co-workers. Illustration by Lutz Kupferschläger.

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来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).