多巴喹的氘标记

IF 0.9 Q4 CHEMISTRY, INORGANIC & NUCLEAR
V. P. Shevchenko, I. Yu. Nagaev, K. V. Shevchenko, N. F. Myasoedov
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引用次数: 0

摘要

研究了将氘引入多巴喹(一种由醌和多巴胺片段组成的化合物)的可能性。同位素交换可以在三氟乙酸(TFA)和HCl存在的情况下与氘化水进行。TFA在80°С时效果最好。为了激活同位素交换,除了酸组分外,还在反应混合物中加入了基于铱或钯的催化剂(5% Pd/Al2O3, cyclocta -1,5-dienyliridium(I) 1,1,1,5,5,5-六氟戊烷-2,4-二酸盐)。用重水(D2O: TFA 5:1, 80°С, 3 h)进行同位素交换制备[D]dopaquine,产率为20%,氘含量在1.2 ~ 1.4个原子/分子之间。多巴胺片段中的氘含量为每分子1.2-1.3个原子。醌碎片含有大约4-7%的同位素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Deuterium Labeling of Dopaquine

Deuterium Labeling of Dopaquine

The possibility of introducing deuterium into dopaquine, a compound consisting of quinone and dopamine fragments, was examined. The isotope exchange can be carried out with deuterated water in the presence of trifluoroacetic acid (TFA) and HCl. The best results were obtained with TFA at 80°С. To activate isotope exchange, catalysts based on iridium or palladium (5% Pd/Al2O3, cycloocta-1,5-dienyliridium(I) 1,1,1,5,5,5-hexafluoropentane-2,4-dionate) were added to the reaction mixture in addition to the acid component. The preparative synthesis of [D]dopaquine was carried out by isotope exchange with deuterated water (D2O : TFA 5 : 1, 80°С, 3 h). [D]Dopaquine was obtained in 20% yield with the deuterium content in the interval 1.2–1.4 atoms per molecule. The deuterium content in the dopamine fragment is 1.2–1.3 atoms per molecule. The quinone fragment contained approximately 4–7% of the isotope.

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来源期刊
Radiochemistry
Radiochemistry CHEMISTRY, INORGANIC & NUCLEAR-
CiteScore
1.30
自引率
33.30%
发文量
51
期刊介绍: Radiochemistry  is a journal that covers the theoretical and applied aspects of radiochemistry, including basic nuclear physical properties of radionuclides; chemistry of radioactive elements and their compounds; the occurrence and behavior of natural and artificial radionuclides in the environment; nuclear fuel cycle; radiochemical analysis methods and devices; production and isolation of radionuclides, synthesis of labeled compounds, new applications of radioactive tracers; radiochemical aspects of nuclear medicine; radiation chemistry and after-effects of nuclear transformations.
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