固定化钪同位素纳米金刚石悬浮液的制备及体内研究

IF 0.9 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Radiochemistry Pub Date : 2025-02-17 DOI:10.1134/S1066362224060110

A. G. Kazakov, D. V. Pavlova, I. A. Ushakov, E. A. Nesterov, V. S. Skuridin, E. A. Odintsova, S. E. Vinokurov, B. F. Myasoedov

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引用次数: 0

摘要

确定了用固定钪溶液制备爆轰合成纳米金刚石悬浮液的条件，该溶液满足以药用同位素44Sc和47Sc为基础的放射性药物静脉给药溶液的要求。证明了钪与ND样品在具有所需pH值和含有最小ND量的等渗溶液中定量结合的可能性。在最佳条件下测定了最有前途的ND样品的Freundlich和Langmuir吸附等温线参数和ΔG吸附量。用固定化钪同位素制备nd的条件将允许在未来进行体内研究。

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Preparation of a Nanodiamond Suspension with Immobilized Scandium Isotopes for in vivo Studies

Conditions were determined for preparing a suspension of detonation synthesis nanodiamonds (NDs) with immobilized scandium in solutions, meeting the requirements to solutions for intravenous administration of radiopharmaceuticals based on the medicinal isotopes ⁴⁴Sc and ⁴⁷Sc. The possibility of the quantitative binding of scandium with ND samples in isotonic solutions having the required pH and containing the minimal ND amount was demonstrated. The Freundlich and Langmuir adsorption isotherm parameters and ΔG of adsorption were determined for the most promising ND sample under the optimum conditions. The conditions found for preparing NDs with immobilized scandium isotopes will allow in vivo studies in the future.

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来源期刊

Radiochemistry CHEMISTRY, INORGANIC & NUCLEAR-

CiteScore

1.30

自引率

33.30%

发文量

期刊介绍： Radiochemistry is a journal that covers the theoretical and applied aspects of radiochemistry, including basic nuclear physical properties of radionuclides; chemistry of radioactive elements and their compounds; the occurrence and behavior of natural and artificial radionuclides in the environment; nuclear fuel cycle; radiochemical analysis methods and devices; production and isolation of radionuclides, synthesis of labeled compounds, new applications of radioactive tracers; radiochemical aspects of nuclear medicine; radiation chemistry and after-effects of nuclear transformations.