牙周炎是痴呆的危险因素：一项系统回顾和荟萃分析

IF 4 4区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Evidence-Based Dental Practice Pub Date : 2025-01-23 DOI:10.1016/j.jebdp.2025.102094

DONG-HEE KIM, GYEONG-SOON HAN

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引用次数: 0

摘要

牙周炎和痴呆之间的关系仍然存在争议。因此，我们分析了这种关联，重点关注牙周炎的严重程度和痴呆的类型。方法检索PubMed、Embase、Web of Science和灰色文献（OpenGrey、ProQuest）数据库，检索时间为2021年6月30日，汇总数据进行meta分析。采用固定效应或随机效应模型来计算优势比（ORs）、风险比（hr）和95%置信区间（ci），以评估牙周炎和痴呆之间的关联强度。结果共纳入13项病例对照研究和11项队列研究。对所有研究的分析表明牙周炎和痴呆之间存在关联，OR为2.26 (95% CI, 1.65−3.09；P & lt;0.0001)， HR为1.15 (95% CI, 1.04−1.27； =考虑 页)。根据牙周炎严重程度，痴呆风险与牙周炎严重程度显著相关(OR = 2.85；95% ci, 2.16−3.74；P = .038)，但与中度以下牙周炎无关(OR = 0.94；95% ci, 0.64−1.40； = 点页)。特别是，患有严重牙周炎的患者患阿尔茨海默氏痴呆症的风险高出6.87倍(OR = 6.87；95% ci, 2.55−18.54；P = .04)，认知功能障碍风险增加2.92倍(OR = 2.92,95% CI, 2.15−3.96； = 。36页)。结论：我们发现牙周炎和痴呆之间有很强的联系，严重的牙周炎被认为是阿尔茨海默氏痴呆的潜在危险因素。因此，及时管理牙周炎以防止其发展可能有助于预防痴呆。

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PERIODONTITIS AS A RISK FACTOR FOR DEMENTIA: A SYSTEMATIC REVIEW AND META-ANALYSIS

Introduction

The association between periodontitis and dementia remains controversial. Therefore, we analyzed this association focusing on the severity of periodontitis and type of dementia.

Methods

We searched the PubMed, Embase, Web of Science, and gray literature (OpenGrey, ProQuest) databases from inception to June 30, 2021, and pooled the data for meta-analysis. Fixed- or random-effects models were employed to calculate odds ratios (ORs), hazard ratios (HRs), and 95% confidence intervals (CIs) to evaluate the strength of the associations between periodontitis and dementia.

Results

Thirteen case-control and 11 cohort studies were selected. The analysis of entire studies indicated an association between periodontitis and dementia, with an OR of 2.26 (95% CI, 1.65−3.09; P < .0001) and HR of 1.15 (95% CI, 1.04−1.27; P = .0006). According to periodontitis severity, the risk of dementia was significantly associated with severe periodontitis (OR = 2.85; 95% CI, 2.16−3.74; P = .038), but not with less-than-moderate periodontitis (OR = 0.94; 95% CI, 0.64−1.40; P = .66). In particular, patients with severe periodontitis had a 6.87-fold higher risk of Alzheimer's dementia (OR = 6.87; 95% CI, 2.55−18.54; P = .04) and 2.92-fold higher risk of cognitive impairment (OR = 2.92, 95% CI, 2.15−3.96; P = .36).

Conclusions

We found a strong association between periodontitis and dementia, with severe periodontitis identified as a potential risk factor for Alzheimer's dementia. Therefore, timely management of periodontitis to prevent its progression may help prevent dementia.

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来源期刊

Journal of Evidence-Based Dental Practice DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

6.00

自引率

16.70%

发文量

105

审稿时长

28 days

期刊介绍： The Journal of Evidence-Based Dental Practice presents timely original articles, as well as reviews of articles on the results and outcomes of clinical procedures and treatment. The Journal advocates the use or rejection of a procedure based on solid, clinical evidence found in literature. The Journal''s dynamic operating principles are explicitness in process and objectives, publication of the highest-quality reviews and original articles, and an emphasis on objectivity.