两种具有抗幽门螺杆菌活性的5,6,7,8-四氢-2-（2-苯乙基）羟色胺

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-02-17 DOI:10.1016/j.phytol.2025.01.1002

Ke-Xin Qin , Hao Wang , Li Yang , Yan-Mei Wei , Cai-Hong Cai , Hui-Qin Chen , Wen-Hua Dong , Wei Li , Xian-Yun Yan , Jun Zeng , Wen-Li Mei , Jie Jian , Haofu Dai

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引用次数: 0

摘要

从沉香的乙醇提取物中分离得到两个新的5,6,7,8-四氢-2-（2-苯乙基）激素（1和2）和一个已知化合物(3)。通过HR-ESI-MS、1D和2D NMR、TDDFT-ECD以及与文献资料的比较，对化合物1和2的结构进行了精确的鉴定。对所有化合物的抗幽门螺杆菌活性进行了评价。化合物2对幽门螺杆菌具有明显的抑制作用，最小抑制浓度（MIC）为20 µM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Two unprecedented 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones with anti-Helicobacter pylori activity from agarwood of Aquilaria sinensis 'Reke 1'

Two new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones (1 and 2), together with one known compound (3), were isolated from the ethanol extract of agarwood produced from Aquilaria sinensis 'Reke 1'. The structures of compounds 1 and 2 were precisely elucidated on the basis of HR-ESI-MS, 1D and 2D NMR, TDDFT-ECD, as well as by comparison with the literature data. All compounds were evaluated for anti-Helicobacter pylori activity. Compound 2 exhibited significant inhibitory effect against H. pylori with the minimum inhibition concentration (MIC) value of 20 µM.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.