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IF 6.4 1区医学 Q1 CELL & TISSUE ENGINEERING

npj Regenerative Medicine Pub Date : 2025-02-14 DOI:10.1038/s41536-025-00396-0

Sarah Barbara Zwingelberg, Gizem Karabiyik, Paul Gehle, Melanie von Brandenstein, Sabina Eibichova, Christian Lotz, Florian Groeber-Becker, Daniel Kampik, Ula Jurkunas, Gerd Geerling, Gregor Lang

引用次数: 0

摘要

角膜疾病是全球第三大致盲原因。戴斯麦特膜内皮角膜成形术（DMEK）是治疗角膜内皮疾病的首选手术技术，主要依赖于高质量的供体组织。然而，合适供体组织的稀缺性和内皮细胞的敏感性仍是重大挑战。这篇综述探讨了 DMEK 的现状，重点关注组织工程学的进展，它是一种很有前景的解决方案，可改善疗效并解决供体限制问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advancements in bioengineering for descemet membrane endothelial keratoplasty (DMEK).

Corneal diseases are the third leading cause of blindness worldwide. Descemet's Membrane Endothelial Keratoplasty (DMEK) is the preferred surgical technique for treating corneal endothelial disorders, relying heavily on high-quality donor tissue. However, the scarcity of suitable donor tissue and the sensitivity of endothelial cells remain significant challenges. This review explores the current state of DMEK, focusing on advancements in tissue engineering as a promising solution to improve outcomes and address donor limitations.

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来源期刊

npj Regenerative Medicine Engineering-Biomedical Engineering

CiteScore

10.00

自引率

1.40%

发文量

审稿时长

12 weeks

期刊介绍： Regenerative Medicine, an innovative online-only journal, aims to advance research in the field of repairing and regenerating damaged tissues and organs within the human body. As a part of the prestigious Nature Partner Journals series and in partnership with ARMI, this high-quality, open access journal serves as a platform for scientists to explore effective therapies that harness the body's natural regenerative capabilities. With a focus on understanding the fundamental mechanisms of tissue damage and regeneration, npj Regenerative Medicine actively encourages studies that bridge the gap between basic research and clinical tissue repair strategies.