包括CAP在内的ARIs的rsv相关住院发生率：来自德国前瞻性ThEpiCAP研究的数据。

IF 14.3 1区医学 Q1 INFECTIOUS DISEASES

Journal of Infection Pub Date : 2025-02-12 DOI:10.1016/j.jinf.2025.106440

Caihua Liang , Elizabeth Begier , Stefan Hagel , Juliane Ankert , Liz Wang , Claudia Schwarz , Lea J. Bayer , Christof von Eiff , Qing Liu , Jo Southern , Jeffrey Vietri , Sonal Uppal , Bradford D. Gessner , Christian Theilacker , Mathias W. Pletz

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引用次数: 0

摘要

背景：RSV是老年人急性呼吸道感染（包括急性呼吸道感染）的主要原因。现有数据往往低估了呼吸道合胞病毒急性呼吸道感染的发病率。我们从一项前瞻性CAP研究中估计了RSV相关的ARI住院发生率，调整了仅因鼻咽/鼻拭子检测而未确诊的RSV感染。方法：在2021-2023年期间对德国成人CAP住院进行主动监测。对鼻咽/鼻拭子进行rsv检测，并采用年龄组特定比例计算rsv相关的CAP发病率。将其除以与呼吸道合胞病毒相关的ARI住院患者的CAP比例（来自多样本研究），以推断与呼吸道合胞病毒相关的ARI发病率。结果：1040例CAP放射学确诊病例中，经鼻咽/鼻拭子检测rsv阳性的占3.7%，剔除未检出因素后为7.8%。对于18-59岁和≥60岁的患者，校正rsv相关CAP住院率（95% CI）分别为4.9（1.8-10.9）和115.6（78.8-163.6）。调整后的rsv相关ARI住院率分别为19.8(6.8-50.1)/ 10万和401.6(260.7-609.3)/ 10万。在rsv相关的CAP入院30天内，≥65岁的患者中有18.2%死亡，18-64岁和≥65岁的患者中分别有11.1%和36.4%发生心血管事件。结论：德国老年人经历了与呼吸道合胞病毒相关的ARI住院的高负担，包括CAP，强调了呼吸道合胞病毒疫苗接种对这一人群的潜在效用。

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Incidence of RSV-related hospitalizations for ARIs, including CAP: Data from the German prospective ThEpiCAP study

Background

RSV is a leading cause of ARI, including CAP, in older adults. Data available often underestimate RSV-related ARI incidence. We estimated RSV-related ARI hospitalization incidence from a prospective CAP study, adjusting for undiagnosed RSV infections due to nasopharyngeal/nasal swab testing only.

Methods

Active surveillance of adult CAP hospitalizations in Germany was conducted between 2021–2023. Nasopharyngeal/nasal swabs were RSV-tested, and age-group specific proportions were applied to calculate RSV-related CAP incidence. This was divided by the CAP proportions among RSV-related ARI hospitalizations (from multispecimen study) to extrapolate RSV-related ARI rates.

Results

Among 1040 radiologically confirmed CAP cases, 3.7% tested RSV-positive via nasopharyngeal/nasal swab, corresponding to 7.8% after adjusting for underdetection. For 18–59 and ≥60 years, adjusted RSV-related CAP hospitalization rates (95% CI) were 4.9 (1.8–10.9) and 115.6 (78.8–163.6); adjusted RSV-related ARI hospitalization rates were 19.8 (6.8–50.1) and 401.6 (260.7–609.3) per 100,000, respectively. Within 30 days of an RSV-related CAP admission, 18.2% of those ≥65 years died, and 11.1% and 36.4% had cardiovascular events among those 18–64 and ≥65 years, respectively.

Conclusions

Older adults in Germany experience a high burden of RSV-related ARI hospitalizations, including CAP, underscoring RSV vaccination’s potential utility for this population.

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来源期刊

Journal of Infection 医学-传染病学

CiteScore

45.90

自引率

3.20%

发文量

475

审稿时长

16 days

期刊介绍： The Journal of Infection publishes original papers on all aspects of infection - clinical, microbiological and epidemiological. The Journal seeks to bring together knowledge from all specialties involved in infection research and clinical practice, and present the best work in the ever-changing field of infection. Each issue brings you Editorials that describe current or controversial topics of interest, high quality Reviews to keep you in touch with the latest developments in specific fields of interest, an Epidemiology section reporting studies in the hospital and the general community, and a lively correspondence section.