内在无序蛋白的膜结合。

IF 10.4 1区 生物学 Q1 BIOPHYSICS
Matthew MacAinsh, Fidha Nazreen Kunnath Muhammedkutty, Ramesh Prasad, Huan-Xiang Zhou
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引用次数: 0

摘要

现在很清楚,内在无序蛋白或内在无序区域的膜结合调节了许多细胞过程,如Src家族激酶的膜靶向和离子通道门控。通过核磁共振波谱、分子动力学模拟和其他技术对残基进行特异性表征表明,多基基和两亲螺旋是膜结合的主要驱动因素;基于序列的残留物特异性膜结合倾向预测已经成为可能。膜结合促进了蛋白质-蛋白质相互作用和蛋白质聚集——这些作用是由于降低了维数,但类似于通过液-液相分离(LLPS)形成的冷凝物。膜表面的LLPS为募集和聚集蛋白质以及膜重塑提供了强有力的手段。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Membrane Association of Intrinsically Disordered Proteins.

It is now clear that membrane association of intrinsically disordered proteins or intrinsically disordered regions regulates many cellular processes, such as membrane targeting of Src family kinases and ion channel gating. Residue-specific characterization by nuclear magnetic resonance spectroscopy, molecular dynamics simulations, and other techniques has shown that polybasic motifs and amphipathic helices are the main drivers of membrane association; sequence-based prediction of residue-specific membrane association propensity has become possible. Membrane association facilitates protein-protein interactions and protein aggregation-these effects are due to reduced dimensionality but are similar to those afforded by condensate formation via liquid-liquid phase separation (LLPS). LLPS at the membrane surface provides a powerful means for recruiting and clustering proteins, as well as for membrane remodeling.

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来源期刊
Annual Review of Biophysics
Annual Review of Biophysics 生物-生物物理
CiteScore
21.00
自引率
0.00%
发文量
25
期刊介绍: The Annual Review of Biophysics, in publication since 1972, covers significant developments in the field of biophysics, including macromolecular structure, function and dynamics, theoretical and computational biophysics, molecular biophysics of the cell, physical systems biology, membrane biophysics, biotechnology, nanotechnology, and emerging techniques.
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