对电休克治疗的反应与更多样化的口腔微生物群有关-一项前瞻性纵向队列试点研究。

IF 3.5 3区医学 Q1 CLINICAL NEUROLOGY

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-02-14 DOI:10.1007/s00406-025-01976-3

Christoph Ammer-Herrmenau, Jacob Hamm, Albrecht Neesse, Kilian Günther, Matthias Besse, David Zilles-Wegner

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引用次数: 0

摘要

最近有研究表明，精神疾病与宿主微生物群的变化有关。关于电惊厥治疗（ECT）和微生物组改变的关联知之甚少。在我们的初步研究中，我们前瞻性地招募了15名患有严重或治疗难治性抑郁症的患者，并在ect之前和之后收集了口腔拭子。与对照组相比，ECT在纵向样本中没有导致显著的微生物转移（p = 0.65）。然而，在ECT前（观察物种p = 0.014, Shannon p = 0.03）和ECT后（观察物种p = 0.015, Shannon p = 0.13），反应者和非反应者之间的α多样性测量差异显著。

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Response to electroconvulsive therapy is associated with a more diverse oral microbiome- a prospective longitudinal cohort pilot study.

Recently it has been shown that psychiatric disorders are associated with changes in the host microbiome. Little is known about the association of electroconvulsive therapy (ECT) and microbiome alterations. In our pilot-study, 15 patients with severe or treatment resistant depression were prospectively recruited and oral swabs were collected pre- and post-ECT. Compared to a control group, ECT did not lead to a significant microbial shift in longitudinal samples (p = 0.65). However, alpha diversity measurements significantly differed between responders and non-responders before ECT (observed species p = 0.014, Shannon p = 0.03) and after ECT (observed species p = 0.015, Shannon p = 0.13).

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来源期刊

European Archives of Psychiatry and Clinical Neuroscience 医学-精神病学

CiteScore

8.80

自引率

4.30%

发文量

154

审稿时长

6-12 weeks

期刊介绍： The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.