Constanze Scholman, Jeroen M Westra, Manon A Zwakenberg, Jan Wedman, Bert van der Vegt, Roel J H M Steenbakkers, Sjoukje F Oosting, Gyorgy B Halmos, Bernard F A M van der Laan, Boudewijn E C Plaat
{"title":"软性喉镜白光与窄带成像检测咽喉癌化疗后局部复发的比较：一项随机对照试验。","authors":"Constanze Scholman, Jeroen M Westra, Manon A Zwakenberg, Jan Wedman, Bert van der Vegt, Roel J H M Steenbakkers, Sjoukje F Oosting, Gyorgy B Halmos, Bernard F A M van der Laan, Boudewijn E C Plaat","doi":"10.1111/coa.14293","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Early detection of local recurrences in patients with head and neck squamous cell carcinoma (HNSCC) is crucial for long-term survival. Aim of this study was to compare white light (WL) imaging with narrow band imaging (NBI) during flexible laryngoscopy for detection of local recurrences and evaluate the effects on clinical outcome in patients with HNSCC treated with radiotherapy ± chemotherapy ((C)RT).</p><p><strong>Design: </strong>Prospective randomised controlled trial.</p><p><strong>Setting: </strong>Tertiary head and neck oncologic center.</p><p><strong>Participants: </strong>257 patients without residual disease after (C)RT were randomised in a WL group (n = 120) or WL-NBI group (n = 137) and followed for 24 months.</p><p><strong>Main outcome measures: </strong>Local recurrence rate and overall survival, disease-specific survival, disease-free survival and local recurrence-free survival were compared between both groups.</p><p><strong>Results: </strong>Detection rate of local recurrences was the same in both groups: 11.7% in WL-NBI and 10.0% in WL (p > 0.05). Overall survival (WL: 88.3%, WL-NBI: 87.6%), disease-specific survival (WL: 86.7%, NBI: 83.9%), disease-free survival (WL: 85.0%, WL-NBI: 83.2%) and local recurrence-free survival (WL: 90.0%, WL-NBI: 89.1%) showed no superiority in the WL-NBI group (p > 0.05).</p><p><strong>Conclusions: </strong>Local recurrence rates are relatively low in the first 24 months after (C)RT for HNSCC. WL-NBI did not improve the detection of local recurrences nor the survival compared to WL.</p><p><strong>Trial registration: </strong>This randomised clinical trial was registered at the research register UMCG with the number 201500918.</p>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of White Light With Narrow Band Imaging Using Flexible Laryngoscopy for the Detection of Local Recurrences After (Chemo)Radiation for Pharyngeal or Laryngeal Cancer: A Randomised Controlled Trial.\",\"authors\":\"Constanze Scholman, Jeroen M Westra, Manon A Zwakenberg, Jan Wedman, Bert van der Vegt, Roel J H M Steenbakkers, Sjoukje F Oosting, Gyorgy B Halmos, Bernard F A M van der Laan, Boudewijn E C Plaat\",\"doi\":\"10.1111/coa.14293\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Early detection of local recurrences in patients with head and neck squamous cell carcinoma (HNSCC) is crucial for long-term survival. Aim of this study was to compare white light (WL) imaging with narrow band imaging (NBI) during flexible laryngoscopy for detection of local recurrences and evaluate the effects on clinical outcome in patients with HNSCC treated with radiotherapy ± chemotherapy ((C)RT).</p><p><strong>Design: </strong>Prospective randomised controlled trial.</p><p><strong>Setting: </strong>Tertiary head and neck oncologic center.</p><p><strong>Participants: </strong>257 patients without residual disease after (C)RT were randomised in a WL group (n = 120) or WL-NBI group (n = 137) and followed for 24 months.</p><p><strong>Main outcome measures: </strong>Local recurrence rate and overall survival, disease-specific survival, disease-free survival and local recurrence-free survival were compared between both groups.</p><p><strong>Results: </strong>Detection rate of local recurrences was the same in both groups: 11.7% in WL-NBI and 10.0% in WL (p > 0.05). Overall survival (WL: 88.3%, WL-NBI: 87.6%), disease-specific survival (WL: 86.7%, NBI: 83.9%), disease-free survival (WL: 85.0%, WL-NBI: 83.2%) and local recurrence-free survival (WL: 90.0%, WL-NBI: 89.1%) showed no superiority in the WL-NBI group (p > 0.05).</p><p><strong>Conclusions: </strong>Local recurrence rates are relatively low in the first 24 months after (C)RT for HNSCC. 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Comparison of White Light With Narrow Band Imaging Using Flexible Laryngoscopy for the Detection of Local Recurrences After (Chemo)Radiation for Pharyngeal or Laryngeal Cancer: A Randomised Controlled Trial.
Objectives: Early detection of local recurrences in patients with head and neck squamous cell carcinoma (HNSCC) is crucial for long-term survival. Aim of this study was to compare white light (WL) imaging with narrow band imaging (NBI) during flexible laryngoscopy for detection of local recurrences and evaluate the effects on clinical outcome in patients with HNSCC treated with radiotherapy ± chemotherapy ((C)RT).
Design: Prospective randomised controlled trial.
Setting: Tertiary head and neck oncologic center.
Participants: 257 patients without residual disease after (C)RT were randomised in a WL group (n = 120) or WL-NBI group (n = 137) and followed for 24 months.
Main outcome measures: Local recurrence rate and overall survival, disease-specific survival, disease-free survival and local recurrence-free survival were compared between both groups.
Results: Detection rate of local recurrences was the same in both groups: 11.7% in WL-NBI and 10.0% in WL (p > 0.05). Overall survival (WL: 88.3%, WL-NBI: 87.6%), disease-specific survival (WL: 86.7%, NBI: 83.9%), disease-free survival (WL: 85.0%, WL-NBI: 83.2%) and local recurrence-free survival (WL: 90.0%, WL-NBI: 89.1%) showed no superiority in the WL-NBI group (p > 0.05).
Conclusions: Local recurrence rates are relatively low in the first 24 months after (C)RT for HNSCC. WL-NBI did not improve the detection of local recurrences nor the survival compared to WL.
Trial registration: This randomised clinical trial was registered at the research register UMCG with the number 201500918.
期刊介绍：
Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with:
current otorhinolaryngological practice
audiology, otology, balance, rhinology, larynx, voice and paediatric ORL
head and neck oncology
head and neck plastic and reconstructive surgery
continuing medical education and ORL training
The emphasis is on high quality new work in the clinical field and on fresh, original research.
Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject.
• Negative/null results
In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.
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