Tiankuo Gao, Dina Suolitiken, Chun Yang, Chaofan Wu, Lingbo He, Yini Wang
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引用次数: 0
摘要
噬血细胞性淋巴组织细胞增多症（HLH）是一种严重的疾病，其特征是不受控制的过度炎症。依托泊苷已被用作儿科HLH的治疗选择；然而，其有效性和成人诱导治疗的必要性仍不清楚。本系统综述和荟萃分析旨在评估依托泊苷诱导治疗成人HLH的有效性，重点关注总反应（OR）。我们于2023年12月11日进行了系统的文献检索，以确定相关研究，结果将7项研究纳入分析。汇总数据显示，与未接受依托泊苷治疗的患者相比，成年HLH患者接受依托泊苷治疗的OR有显著改善（1.95,95% CI 1.51-2.53）。此外，依托泊苷治疗提高了总生存率（1.25,95% CI 1.03-1.52）。我们的分析揭示了依托泊苷为基础的治疗对成年HLH患者的潜在益处。因此，依托泊苷应被视为治疗成人HLH的一种及时和早期的治疗选择。
Assessing the effectiveness of etoposide treatment in adult haemophagocytic lymphohistiocytosis: a systematic review and meta-analysis.
Haemophagocytic lymphohistiocytosis (HLH) is a serious condition characterised by uncontrolled hyperinflammation. Etoposide has been used as a treatment option in paediatric HLH; however, its effectiveness and the necessity for adult induction therapy remain unclear. This systematic review and meta-analysis aimed to assess the effectiveness of etoposide-based induction therapy in adult HLH, focusing on overall response (OR). A systematic literature search was conducted to identify relevant studies on 11 December 2023, resulting in the inclusion of seven studies in the analysis. The pooled data demonstrated a significant improvement in OR with etoposide-based therapy in adult patients with HLH (1.95, 95% CI 1.51-2.53), compared with non-etoposide-treated patients. Furthermore, overall survival improved with etoposide treatment (1.25, 95% CI 1.03-1.52). Our analysis revealed the potential benefit of etoposide-based therapy in adult patients with HLH. Therefore, etoposide should be considered as a timely and early therapeutic option for the management of adult HLH.
期刊介绍：
Clinical and Experimental Medicine (CEM) is a multidisciplinary journal that aims to be a forum of scientific excellence and information exchange in relation to the basic and clinical features of the following fields: hematology, onco-hematology, oncology, virology, immunology, and rheumatology. The journal publishes reviews and editorials, experimental and preclinical studies, translational research, prospectively designed clinical trials, and epidemiological studies. Papers containing new clinical or experimental data that are likely to contribute to changes in clinical practice or the way in which a disease is thought about will be given priority due to their immediate importance. Case reports will be accepted on an exceptional basis only, and their submission is discouraged. The major criteria for publication are clarity, scientific soundness, and advances in knowledge. In compliance with the overwhelmingly prevailing request by the international scientific community, and with respect for eco-compatibility issues, CEM is now published exclusively online.
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