我在1975年撰写的《肌醇磷脂和细胞表面受体功能》综述是在什么科学背景下进行的?

IF 3.9 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Robert H. (Bob) Michell
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引用次数: 0

摘要

在我的mba评论发表50 年之后,我很高兴地听到,许多研究“多重宇宙磷酸肌苷”的现任领导者正在为一本权威的关于细胞功能宇宙论现状的文章集子做出贡献——另外三位来自伯明翰的磷酸肌苷专家正在汇编这本集子。20世纪80年代初,当磷酸肌醇酶C信号通路成为细胞调控的焦点时,它引起了大多数生物学家一直忽视的代谢非典型膜磷脂家族的注意。回顾过去,值得注意的是,有多少重要的线索已经在文献中徘徊,等待我们在20世纪70年代开始理解它们。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
What was the scientific context in which I wrote my 1975 “Inositol phospholipids and cell surface receptor function” review?
50 years on from my BBA review, I was delighted to hear that many of the current leaders of research across “The Multiverse of Phosphoinositides” are contributing to an authoritative collection of articles on the current state of that cosmology of cell functions – and that three other inositidonauts who were launched from Birmingham are assembling it. When the phosphoinositidase C signalling pathway emerged into the cell regulation limelight during the early 1980s it drew attention to a family of metabolically atypical membrane phospholipids that most biologists had been comfortably ignoring. Looking back, it is remarkable how many important clues were already loitering in the literature, waiting for us to start to make sense of them in the 1970s.
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来源期刊
CiteScore
11.00
自引率
2.10%
发文量
109
审稿时长
53 days
期刊介绍: BBA Molecular and Cell Biology of Lipids publishes papers on original research dealing with novel aspects of molecular genetics related to the lipidome, the biosynthesis of lipids, the role of lipids in cells and whole organisms, the regulation of lipid metabolism and function, and lipidomics in all organisms. Manuscripts should significantly advance the understanding of the molecular mechanisms underlying biological processes in which lipids are involved. Papers detailing novel methodology must report significant biochemical, molecular, or functional insight in the area of lipids.
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