{"title":"作为 AAA 潜在治疗靶点的 TRPM7 通道","authors":"Ryan Laloo, Marc Bailey","doi":"10.1038/s44161-024-00598-7","DOIUrl":null,"url":null,"abstract":"TRPM7 channel interference protects against abdominal aortic aneurysm (AAA) formation and progression in mice by regulating phenotypic switching of vascular smooth muscle cells, extracellular matrix degradation and vessel wall inflammation, all of which are hallmark features of abdominal aortic aneurysm pathogenesis.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 2","pages":"126-128"},"PeriodicalIF":9.4000,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"TRPM7 channel as a potential therapeutic target for AAA\",\"authors\":\"Ryan Laloo, Marc Bailey\",\"doi\":\"10.1038/s44161-024-00598-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"TRPM7 channel interference protects against abdominal aortic aneurysm (AAA) formation and progression in mice by regulating phenotypic switching of vascular smooth muscle cells, extracellular matrix degradation and vessel wall inflammation, all of which are hallmark features of abdominal aortic aneurysm pathogenesis.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"4 2\",\"pages\":\"126-128\"},\"PeriodicalIF\":9.4000,\"publicationDate\":\"2025-02-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-024-00598-7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-024-00598-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
TRPM7 channel as a potential therapeutic target for AAA
TRPM7 channel interference protects against abdominal aortic aneurysm (AAA) formation and progression in mice by regulating phenotypic switching of vascular smooth muscle cells, extracellular matrix degradation and vessel wall inflammation, all of which are hallmark features of abdominal aortic aneurysm pathogenesis.
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