声门上喉鳞癌中PD-L1表达及相关肿瘤浸润淋巴细胞的预后意义

IF 2.2 4区 医学 Q4 IMMUNOLOGY
Apmis Pub Date : 2025-02-17 DOI:10.1111/apm.70005
Elvir Zvrko, Muhedin Kadic, Ljiljana Vuckovic
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引用次数: 0

摘要

喉鳞状细胞癌(LSCC)的特点是肿瘤浸润淋巴细胞(til)的多样性。我们的目的是研究TILs和程序性死亡配体1 (PD-L1)在声门上LSCC患者中的潜在预后作用。应用免疫组化技术对39例原发性声门上LSCC患者的PD-L1和TILs的表达进行了评估,并与临床病理特征和无病生存期(DFS)进行了相关性分析。使用Kaplan-Meier法测量生存曲线,使用log-rank检验估计组间生存差异。pd - l1阳性(联合阳性评分:CPS≥1)患者TIL密度显著高于pd - l1阴性(CPS < 1)患者(p = 0.000)。较低的PD-L1表达与局部复发显著相关(Fisher精确检验,p = 0.008)。CPS≥1的患者的DFS明显长于CPS <; 1的患者(Log-rank检验,p = 0.004)。多因素Cox回归分析显示,低CPS (p = 0.003)和阳性淋巴结状态(p = 0.012)是恶性肿瘤复发的独立预测因子,具有统计学意义。PD-L1是预测最终治疗后复发和缩短生存期的一个有价值的指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Prognostic Significance of PD-L1 Expression and Associated Tumor-Infiltrating Lymphocytes in Supraglottic Laryngeal Squamous Cell Carcinoma

Laryngeal squamous cell carcinoma (LSCC) is characterized by diverse profiles of tumor-infiltrating lymphocytes (TILs). We aimed to investigate the potential prognostic role of TILs and programmed death-ligand 1 (PD-L1) in patients with supraglottic LSCC. The expression of PD-L1 and TILs was assessed using immunohistochemistry in 39 patients with primary supraglottic LSCC and correlated with clinicopathological characteristics and disease-free survival (DFS). Survival curves were measured using the Kaplan–Meier method, and differences in survival between the groups were estimated using the log-rank test. TIL density was significantly higher in PD-L1-positive (combined positive score: CPS ≥ 1) than in PD-L1-negative (CPS < 1) patients (p = 0.000). Lower PD-L1 expression was significantly associated with a locoregional recurrence (Fisher's exact test, p = 0.008). DFS was significantly longer in patients with CPS ≥ 1 than in those with CPS < 1 (Log-rank test, p = 0.004). Multivariate Cox regression analysis showed that a low CPS (p = 0.003) and positive nodal status (p = 0.012) were statistically significant and independent predictors of malignancy recurrence. PD-L1 represents a valuable marker for predicting recurrence and shorter survival after definitive therapy.

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来源期刊
Apmis
Apmis 医学-病理学
CiteScore
5.20
自引率
0.00%
发文量
91
审稿时长
2 months
期刊介绍: APMIS, formerly Acta Pathologica, Microbiologica et Immunologica Scandinavica, has been published since 1924 by the Scandinavian Societies for Medical Microbiology and Pathology as a non-profit-making scientific journal.
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