小胶质细胞过程α-突触核蛋白原纤维与trem2依赖方式增强其致病性（Adv. Sci. 7/2025）

IF 14.1 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-02-17 DOI:10.1002/advs.202570037

Min Xiong, Danhao Xia, Honglu Yu, Lanxia Meng, Xingyu Zhang, Jiehui Chen, Ye Tian, Xin Yuan, Xuan Niu, Shuke Nie, Zhaohui Zhang, Chaoyang Liu, Qiang Chen, Keqiang Ye, Zhentao Zhang

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引用次数: 0

摘要

在文章编号2413451中，张振涛等人发现，小胶质细胞加工α-突触核蛋白原纤维，生成具有增强毒性的新型原纤维，促进帕金森病的发生和进展。α-突触核蛋白原纤维通过TREM2进入小胶质细胞。然后经天冬酰胺内肽酶加工生成α-突触核蛋白1-103原纤维，其毒性大于原始α-突触核蛋白原纤维。这些结果表明，阻断小胶质细胞的异常活动可以阻止帕金森病的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Microglia Process α-Synuclein Fibrils and Enhance their Pathogenicity in a TREM2-Dependent Manner (Adv. Sci. 7/2025)

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Microglia Process α-Synuclein Fibrils and Enhance their Pathogenicity in a TREM2-Dependent Manner (Adv. Sci. 7/2025)

Parkinson's Disease

In article number 2413451, Zhentao Zhang and co-workers show that microglia process α-synuclein fibrils to generate novel fibrils with enhanced toxicity, promoting the onset and progression of Parkinson's disease. α-Synuclein fibrils enter microglia through TREM2. Then they are processed by asparagine endopeptidase to produce α-synuclein 1-103 fibrils, which are more toxic than naive α-synuclein fibrils. These results show that blocking the aberrant activity of microglia halts the progression of Parkinson's disease.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.