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IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Archives of Osteoporosis Pub Date : 2025-02-16 DOI:10.1007/s11657-025-01505-8

Min Soo Kim, Jeong-Min Yang, Yonghan Cha, Seung Hoon Kim, Minah Park, Jae-Hyun Kim

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引用次数: 0

摘要

摘要本研究的目的是科学、系统地探讨股骨骨折患者骨折联络服务（FLS）的临床有效性。方法使用国际数据库 Ovid-MEDLINE、EMBASE 和 Cochrane 图书馆以及韩国数据库 KISS、RISS、KoreaScience、Koreamed 和 Kmbase。在研究设计层面进行了偏倚风险评估，采用随机效应和固定效应模型进行了荟萃分析，并进行了亚组分析。结果在所选的 32 篇文章中，有 14 篇与继发性骨折相关，18 篇与死亡率相关的文章被纳入荟萃分析。荟萃分析结果显示，参与骨折联络服务组的后续骨折风险比未参与组低 46%，这一差异具有统计学意义（RR = 0.54，95% CI = 0.50-0.59）。参加骨折服务组的死亡风险比未参加组低 17%，这一差异也没有统计学意义（RR = 0.83，95% CI = 0.67-1.03）。结论 FLS 在全球范围内的实施对加强股骨骨折患者的临床管理和治疗起到了至关重要的作用，有助于减少后续骨折和死亡率。这表明，FLS 在最大程度减轻全球股骨骨折相关疾病负担方面发挥了重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The impact of a fracture liaison service for patients with femoral fractures on subsequent fractures and mortality: focusing on systematic literature review and metaanalysis

Summary

The purpose of this study is to scientifically and systematically investigate the clinical effectiveness of a fracture liaison service (FLS) for patients with femoral fractures.

Methods

The international databases Ovid-MEDLINE, EMBASE, and The Cochrane Library and the Korean databases KISS, RISS, KoreaScience, Koreamed, and Kmbase were used. Risk of bias assessment was conducted at the study design level, and meta-analysis utilized both random-effects and fixed-effects models, along with subgroup analysis.

Results

From the 32 selected articles, 14 articles related to subsequent fracture and 18 articles related to mortality were included in the meta-analysis. As a result of the meta-analysis, the risk of subsequent fracture in the group that participated in the fracture liaison service was 46% lower than that in the non-participated group, and this difference was statistically significant (RR = 0.54, 95% CI = 0.50–0.59). The risk of death in the group that participated in the FLS was 17% lower than that in the non-participating group, and this difference was not statistically significant as well (RR = 0.83, 95% CI = 0.67–1.03). As a result of subgroup analysis, there was a statistically significant difference in the reduction of subsequent fracture in the clinical outcomes, and there was a significant difference in mortality in the intervention follow-up period and clinical outcomes.

Conclusion

The global implementation of FLS has played a crucial role in enhancing the clinical management and treatment of patients with femoral fractures, contributing to a decrease in subsequent fracture and mortality. This indicates the significant role of FLS in minimizing the disease burden associated with femoral fractures worldwide.

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来源期刊

Archives of Osteoporosis ENDOCRINOLOGY & METABOLISMORTHOPEDICS -ORTHOPEDICS

CiteScore

5.50

自引率

10.00%

发文量

133

期刊介绍： Archives of Osteoporosis is an international multidisciplinary journal which is a joint initiative of the International Osteoporosis Foundation and the National Osteoporosis Foundation of the USA. The journal will highlight the specificities of different regions around the world concerning epidemiology, reference values for bone density and bone metabolism, as well as clinical aspects of osteoporosis and other bone diseases.